Where youth matters-clinicopathologic characteristics and emerging trends in treatment and outcomes in young Irish women with breast cancer

Irish Journal of Medical Science
Megan GreallyJanice M Walshe

Abstract

Young women with breast cancer (YWBC) represent 7-12% of breast cancer diagnoses and ostensibly have more biologically aggressive subtypes with higher relapse and mortality rates. We studied the clinical and pathological characteristics in YWBC and examined how outcomes and treatment have evolved. YWBC were identified from pathology databases at two tertiary centers. Patients were divided into two cohorts: those diagnosed from 2000 to 2005 (C1) and from 2006 to 2015 (C2). Data were retrieved from clinical, radiology, and histology databases. Statistical analysis was performed using R® (V3.2.0). We identified 345 patients. Median age was 36 years (23-39 years). Mastectomy was performed in 232 patients (67.2%) and axillary lymph node clearance (ALNC) in 207 patients (60% [C1 82.7 vs. C2: 49.4%, p < 0.001]). One hundred-seventy patients (49%) were ER + HER2-, 88 (25.5%) were HER2+, and 58 (16.8%) were triple negative. Eighty patients (23.2%) received neoadjuvant therapy. Pathological complete response rates were statistically similar between C1 and C2 [C1 1 (0.9%) vs C2 16 (6.8%) p = 0.1]. Distant relapse occurred in 59 (19%) patients. There was a higher relapse rate (RR) in C1 [27 (32.1%) vs. 32 (15.7%), p < 0.002). HER2+ and ER+...Continue Reading

References

Jul 17, 1995·International Journal of Cancer. Journal International Du Cancer·P BonnierL Piana
Apr 24, 1993·Lancet·A de la RochefordiereA Fourquet
Aug 29, 2003·The Journal of Surgical Research·Melinda A MaggardClifford Y Ko
Dec 14, 2004·The New England Journal of Medicine·Soonmyung PaikNorman Wolmark
Jun 8, 2006·JAMA : the Journal of the American Medical Association·Lisa A CareyRobert C Millikan
Mar 3, 2007·International Journal of Cancer. Journal International Du Cancer·Marieke W J LouwmanJan Willem W Coebergh
Aug 7, 2008·Breast Cancer Research : BCR·Rulla M TamimiLaura C Collins
Nov 13, 2008·Journal of the National Cancer Institute·Louise A BrintonWilliam F Anderson
Nov 13, 2009·PloS One·Hanna FredholmHenrik Lindman
Feb 2, 2010·The Breast : Official Journal of the European Society of Mastology·L M BacchiF M Carvalho
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Mar 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K David VoducHagen Kennecke
May 11, 2010·Molecular Oncology·Britta WeigeltJorge S Reis-Filho
Oct 1, 2010·Annals of Surgical Oncology·Kay Washington
Apr 12, 2011·Pathology Oncology Research : POR·Adele CaldarellaMarco Zappa
Aug 30, 2011·BMC Cancer·Elrasheid H A KheirelseidMichael J Kerin
Nov 15, 2011·Breast Cancer Research and Treatment·L C CollinsA H Partridge
Feb 4, 2012·International Journal of Radiation Oncology, Biology, Physics·Usama MahmoodSteven Feigenberg
Mar 29, 2012·Breast Cancer Research : BCR·Theresa H M KeeganChristina A Clarke
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Feb 28, 2013·JAMA : the Journal of the American Medical Association·Rebecca H JohnsonArchie Bleyer
Jun 1, 2013·Journal of the National Cancer Institute·Ellen CopsonUNKNOWN POSH Study Steering Group
Apr 29, 2014·The Breast : Official Journal of the European Society of Mastology·Ann H PartridgeFatima Cardoso
Sep 12, 2014·Breast Cancer Research and Treatment·Wilson SheridanChia Stephen
Oct 11, 2014·Journal of Multidisciplinary Healthcare·Chantal Reyna, Marie Catherine Lee
Nov 19, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M GnantUNKNOWN Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria
Dec 2, 2014·Breast Cancer Research : BCR·Hatem A Azim, Ann H Partridge
Mar 23, 2015·Current Treatment Options in Oncology·D RibnikarF Cardoso
May 10, 2015·Annals of Surgical Oncology·Ingrid LizarragaAlexandra Thomas
May 23, 2015·The Breast : Official Journal of the European Society of Mastology·Rafael de Deus MouraCarlos E Bacchi
Sep 10, 2015·BioMed Research International·Minna K LeeHelena R Chang

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Jan 26, 2020·The British Journal of Surgery·S M WalshM L Gemignani

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