Whey protein concentrate enhances intestinal integrity and influences transforming growth factor-β1 and mitogen-activated protein kinase signalling pathways in piglets after lipopolysaccharide challenge

The British Journal of Nutrition
Kan XiaoXinyan Han

Abstract

Whey protein concentrate (WPC) has been reported to have protective effects on the intestinal barrier. However, the molecular mechanisms involved are not fully elucidated. Transforming growth factor-β1 (TGF-β1) is an important component in the WPC, but whether TGF-β1 plays a role in these processes is not clear. The aim of this study was to investigate the protective effects of WPC on the intestinal epithelial barrier as well as whether TGF-β1 is involved in these protection processes in a piglet model after lipopolysaccharide (LPS) challenge. In total, eighteen weanling pigs were randomly allocated to one of the following three treatment groups: (1) non-challenged control and control diet; (2) LPS-challenged control and control diet; (3) LPS+5 %WPC diet. After 19 d of feeding with control or 5 %WPC diets, pigs were injected with LPS or saline. At 4 h after injection, pigs were killed to harvest jejunal samples. The results showed that WPC improved (P<0·05) intestinal morphology, as indicated by greater villus height and villus height:crypt depth ratio, and intestinal barrier function, which was reflected by increased transepithelial electrical resistance and decreased mucosal-to-serosal paracellular flux of dextran (4 kDa), co...Continue Reading

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Citations

Jan 11, 2018·Polish Journal of Microbiology·Judit Szabó-FodorMelinda Kovács
Jun 1, 2018·Experimental and Therapeutic Medicine·Hailing YuDa Li
Sep 22, 2018·Clinical Oral Investigations·Layla PanahipourReinhard Gruber
Jun 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tee Yee SimDaud Ahmad Israf
Jan 26, 2021·Irish Journal of Medical Science·Victoria GriffithsRizwan Khan

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