Which allergen extract for grass pollen immunotherapy? An in vitro study

Immunological Investigations
F MarcucciFranco Frati

Abstract

Grass pollen is a major cause of allergy throughout the world. The only treatment targeting the causes and not only the symptoms of allergy is specific immunotherapy (IT). A number of controlled trials demonstrated the efficacy of IT in grass pollen allergic subjects, most using extracts of multiple grasses but some using extracts of a single grass. The optimal grass extract for IT has not yet been established. This study is aimed at investigating the IgE-binding pattern in sera from IT-naïve patients from central Italy with allergic rhinitis and/or asthma caused by grass pollen. A 5-grass extract was used (containing Dactylis glomerata, Poa pratensis, Lolium perenne, Antoxanthum odoratum and Phleum pratense) and compared to Phleum pratense alone, which is the most frequently used single grass extract, by the RAST-inhibition technique. The 5-grass extract showed, by RAST-inhibition, a significantly higher binding compared to the Phleum pratense extract for Antoxanthum odoratum and Poa pratensis, while the two extracts for immunotherapy showed similar binding affinity for Phleum pratense and the non-Pooideae grass, Cynodon dactylon. The use of a mixed-grass pollen extract seems to be the optimal choice when applying specific IT ...Continue Reading

References

Jun 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R Van ReeR C Aalberse
Nov 15, 2001·The Journal of Allergy and Clinical Immunology·J BousquetUNKNOWN World Health Organization
Apr 4, 2003·International Archives of Allergy and Immunology·Kerstin Andersson, Jonas Lidholm
Oct 3, 2006·Current Opinion in Immunology·Reto Crameri, Claudio Rhyner
Feb 27, 2007·The Journal of Allergy and Clinical Immunology·Mübeccel Akdis, Cezmi A Akdis
May 25, 2007·Allergy·G D'AmatoP van Cauwenberge
Sep 20, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B ErbasM Abramson
Nov 16, 2007·International Archives of Allergy and Immunology·Oscar DuffortFlorentino Polo
Mar 26, 2008·International Archives of Allergy and Immunology·Philippe MoingeonGabriel Peltre
Oct 3, 2008·Clinical Allergy and Immunology·Robert E Esch
Feb 19, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C HejlH Ipsen

❮ Previous
Next ❯

Citations

Mar 30, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ghada BoghdadiSamir Sorour
Mar 28, 2013·Clinical Drug Investigation·Matteo RuggeriAmerico Cicchetti
Feb 18, 2016·The Journal of Allergy and Clinical Immunology·Luise WesternbergBjoern Peters
Apr 9, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L D ArchilaW W Kwok
Oct 25, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K GanglR Valenta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.