PMID: 9557780Apr 29, 1998Paper

Which direction do nevus cells move? Abtropfung reexamined

The American Journal of Dermatopathology
W I Worret, W H Burgdorf

Abstract

In 1893, Unna published his theory of Abtropfung in which he suggested that melanocytic nevus cells originate in the epidermis and drop off into the dermis. We studied 3,534 nevi from patients of all ages to reassess this almost sacred concept. If Unna was correct, one would expect that in childhood most nevi would be junctional, while in late adult life almost all nevi would be intradermal. In our series, no child under age 10 had a purely junctional nevus, 52% had compound nevi, and 48% had dermal nevi. In patients older than age 60, 12% had junctional nevi, 23% had compound nevi, and 65% had dermal nevi. Our data fail to support the concept of Abtropfung; they fit better with the contradictory theory of upward migration of nevus cells.

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Citations

Sep 9, 2005·The American Journal of Dermatopathology·Sven Krengel
Apr 7, 2007·The American Journal of Dermatopathology·Evaristo Sánchez YusMaría Rueda
Feb 24, 2012·The American Journal of Dermatopathology·Angel Fernandez-FloresFrancisco Soto
Mar 28, 2008·The British Journal of Dermatology·A ScopeA C Halpern
Nov 3, 2007·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Iris ZalaudekH Peter Soyer
Jun 8, 2007·The British Journal of Dermatology·G ArgenzianoH P Soyer
Jan 26, 2006·The British Journal of Dermatology·I ZalaudekR Hofmann-Wellenhof
Sep 17, 2004·Pathology·Inara Strungs
Sep 13, 2008·The Journal of Investigative Dermatology·James M Grichnik
Mar 5, 2014·Experimental Dermatology·James M GrichnikKonstantinos E Hatzistergos
Oct 19, 2007·Journal of Cutaneous Medicine and Surgery·Magda MartinkaMartin J Trotter
Apr 22, 2020·Journal of Cutaneous Pathology·Stewart F CramerMiguel Reyes-Múgica
Nov 11, 2011·The Australasian Journal of Dermatology·Peter PiliourasIris Zalaudek
May 27, 2020·Scientific Reports·Caterina LannaLaura Diluvio
Nov 1, 2015·Melanoma Management·Shadi Damanpour, James M Grichnik
Oct 1, 2019·Annals of Dermatology·Fatma Pelin CengizNahide Onsun
May 15, 2007·Annals of Diagnostic Pathology·Dmitry V Kazakov, Michal Michal
Jan 20, 2021·The American Journal of Dermatopathology·Maximilian GassenmaierStephan Forchhammer

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