Which factors enhance positive drug reimbursement recommendation in Scotland? A retrospective analysis 2006-2013

Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Mata CharokopouBart Heeg

Abstract

To identify the factors that influence the Scottish Medicines Consortium (SMC) in deciding whether to accept pharmaceutical technologies for use within the Scottish health care system. A database of SMC submissions between 2006 and 2013 was created, containing a range of clinical, economic, and other factors extracted from published health technology assessment reports. A binomial outcome variable was used, defined as the decision to "accept for use" or "not recommend" a technology. Univariate and multivariate analyses were conducted to assess the impact by means of odds ratios (ORs) of the submitted evidence on the recommendation decision. Out of 463 applications, 265 were accepted for use (57%) and 198 (43%) were not recommended for use within National Health Service Scotland. Univariate analyses showed that 13 variables significantly affected the SMC decision. Of these 13 variables, 7 variables were shown to have a meaningful impact in the multivariate analysis. Four of these concerned the outcome of cost-effectiveness analyses; the fact that a submission was supported by a cost-minimization analysis was the strongest positive variable (OR = 10.30) and a submission showing a product not being cost-effective (i.e., incrementa...Continue Reading

References

Mar 2, 2005·International Journal of Technology Assessment in Health Care·Cynthia P IglesiasUNKNOWN NEVALAT Project Group
Oct 11, 2005·Health Policy·Helen Angela DakinIsaac A O Odeyemi
Dec 13, 2005·The International Journal of Health Planning and Management·Elias Mossialos, Adam Oliver
Apr 6, 2007·British Medical Bulletin·Simon WalkerMark Sculpher
Apr 2, 2008·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Anthony H HarrisEmily Walkom
Aug 15, 2008·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Marco BarbieriMark Sculpher
May 26, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne MasonDennis Raisch
Jul 28, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rebecca TrowmanPeter Clark
Jul 19, 2013·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Karin H CerriJose-Luis Fernandez

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Citations

Sep 28, 2017·Expert Review of Pharmacoeconomics & Outcomes Research·Paweł KawalecWojciech Trąbka
Sep 1, 2018·Expert Review of Pharmacoeconomics & Outcomes Research·Wiesława Dominika WranikMin Hu
Jun 17, 2020·International Journal of Technology Assessment in Health Care·Laia Maynou, John Cairns
Feb 15, 2018·PharmacoEconomics Open·Kavisha JayasundaraPaul Grootendorst
Jun 15, 2019·Journal of Medical Economics·Lieven Annemans

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