Which inotrope for which baby?

Archives of Disease in Childhood. Fetal and Neonatal Edition
N Evans

Abstract

While we know a lot about blood pressure (BP) responses to various inotropes and a bit about systemic and organ blood flow responses, we know almost nothing about how different inotropes affect clinical outcomes. Low systemic blood flow (SBF) is common in the first 24 h after birth in very preterm babies (and more mature babies with severe respiratory problems) and is not always reflected by low BP. The causes of this low SBF are complex but may relate to maladaptation to high extrauterine systemic (and sometimes pulmonary) vascular resistance. After day 1, hypotensive babies are more likely to have normal or high SBF reflecting vasodilatation. Empirically, inotropes that reduce afterload (such as dobutamine) may be more appropriate in the transitional period, while those with more vasoconstrictor actions (such as dopamine) may be more appropriate later on. Defining the haemodynamic in an individual baby needs both BP and echocardiographic measures of SBF. Research in this area needs to move beyond just demonstrating changes in physiological variables to showing improvements in important clinical outcomes.

References

Oct 1, 1979·The Journal of Pediatrics·H C LouH Pedersen
Oct 1, 1992·Archives of Disease in Childhood·N Evans, J Moorcraft
Jan 11, 1992·Journal of Pediatric Surgery·J P KinsellaD M Null
May 1, 1989·Early Human Development·A M WatkinsR W Cooke
Oct 1, 1987·Archives of Disease in Childhood·V M Miall-AllenA G Whitelaw
Dec 1, 1987·Archives of Disease in Childhood·P VanhaesebrouckM Thiery
Sep 1, 1980·The Journal of Pediatrics·J S Wigglesworth
Jul 1, 1993·Archives of Disease in Childhood·J C RozéA Mouzard
Jan 1, 1996·Archives of Disease in Childhood. Fetal and Neonatal Edition·J R SkinnerE N Hey
Mar 1, 1996·Archives of Disease in Childhood. Fetal and Neonatal Edition·N Evans, M Kluckow
Mar 1, 1997·Pediatric Cardiology·Y TakahashiG Takada
May 1, 1997·Archives of Disease in Childhood. Fetal and Neonatal Edition·D Bourchier, P J Weston
Dec 24, 1997·Acta Paediatrica·P PladysC Ecoffey
May 13, 1998·Archives of Disease in Childhood. Fetal and Neonatal Edition·N EvansA Currie
Dec 8, 1998·The Journal of Pediatrics·I SeriJ S Gerdes
Jun 22, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·J H MeekJ S Wyatt
Mar 29, 2000·Early Human Development·K LundstrømG Greisen
Apr 12, 2000·Journal of Paediatrics and Child Health·N Evans
May 5, 2000·Archives of Disease in Childhood. Fetal and Neonatal Edition·M Kluckow, N Evans
May 5, 2000·Archives of Disease in Childhood. Fetal and Neonatal Edition·M Kluckow, N Evans
May 5, 2000·The Cochrane Database of Systematic Reviews·N V Subhedar, N J Shaw
Jun 19, 2001·The Cochrane Database of Systematic Reviews·D A Osborn, N Evans
Aug 7, 2001·The Journal of Pediatrics·M Kluckow, N Evans
Sep 1, 2001·The New England Journal of Medicine·D W Landry, J A Oliver
Feb 28, 2002·The Journal of Pediatrics·David OsbornMartin Kluckow
Apr 16, 2002·The Journal of Pediatrics·Jean-Michel LietJean-Christophe Rozé
Jul 13, 2002·Acta Paediatrica·M HeckmannW Lindner
Feb 20, 2004·The Cochrane Database of Systematic Reviews·M Paradisis, D A Osborn
Feb 24, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·P C NgE Wong
Apr 24, 2004·The Cochrane Database of Systematic Reviews·D A Osborn, N Evans
Nov 3, 2004·The Journal of Pediatrics·Rod W HuntMartin Kluckow
Nov 5, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Erika FernandezKristi Watterberg
Dec 3, 2004·Pediatrics·Michael J MunroCharles P Barfield
Jun 7, 2005·Early Human Development·Gorm Greisen

❮ Previous
Next ❯

Citations

Oct 9, 2013·Seminars in Fetal & Neonatal Medicine·Samir Gupta, Steven M Donn
Apr 19, 2008·The New England Journal of Medicine·Eric C Eichenwald, Ann R Stark
Apr 27, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·Koert A de WaalMartin Kluckow
Oct 2, 2007·Critical Care : the Official Journal of the Critical Care Forum·Wendy A LuceJohn Anthony Bauer
Feb 1, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·P MontaldoP Giliberti
Aug 1, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·S Ghirardello, F Mosca
Nov 14, 2014·Fetal and Pediatric Pathology·MaJosé Rodríguez-CastañoLuis Arruza
Dec 7, 2006·Clinics in Perinatology·Golde G Dudell, Lucky Jain
May 21, 2013·Jornal de pediatria·Joaquim E B Cabral, Jaques Belik
Oct 15, 2011·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Luc MertensUNKNOWN Association for European Pediatric Cardiologists (AEPC)
May 14, 2016·World Journal of Clinical Pediatrics·Sadaf I BhayatMichael Eisenhut
Aug 7, 2013·Current Hypertension Reports·Alison L Kent, Tejasvi Chaudhari
Aug 9, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Margrete Larsen BurnsUNKNOWN Norwegian Neonatal Network
Nov 29, 2011·Acta Paediatrica·D SweetmanE J Molloy
Jul 10, 2020·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Shubham BakshiRuben Vaidya
Apr 20, 2018·Frontiers in Pediatrics·Cécile TissotNicole Sekarski
May 21, 2015·Indian Journal of Pediatrics·B Vishnu Bhat, Nishad Plakkal
Mar 4, 2020·NeoReviews·Amna Qasim, Sunil K Jain
Jun 6, 2020·Frontiers in Pediatrics·Mary O'DeaEleanor J Molloy
May 8, 2013·Pediatrics·Beau BattonUNKNOWN Eunice Kennedy Shriver National Institute of Child Health & Human Development Neonatal Research Network

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.