Which is the Most Reasonable Anti-aging Strategy: Meta-analysis

Advances in Experimental Medicine and Biology
Yaru Liang, Zhao Wang

Abstract

An organism's lifespan is inevitably accompanied by the aging process, which involves functional decline, a steady increase of a plethora of chronic diseases, and ultimately death. Thus, it has been an ongoing dream of mankind to improve health span and extend the lifespan. In the last century, there is a great increase in the search for eternal youth and an insatiable appetite for methods which could turn back the clock. Survival curves are key components of lifespan experiments. Many interventions have been reported to extend the lifespan, including the administration of pharmaceuticals, calorie restriction, and genetic alteration. However, few studies have attempted to provide a comprehensive analysis of the mechanism by which these various methods function to extend lifespan. We recently collected survival curves from published papers and recovered data by fitting models. The analysis results highlight the overall advantage of calorie restriction and its mimetics in aging and demonstrate that hypoglycemic agents and antioxidants have a superior effect on lifespan extension via a pattern of global integrity compared to other medications. This review provides a scientific foundation for the discovery of effective anti-aging a...Continue Reading

Citations

Dec 22, 2020·Frontiers in Physiology·Aleksei G Golubev
Feb 20, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Christoph Hoog AntinkBergita Ganse
May 18, 2021·International Journal of Sports Medicine·Bergita Ganse, Hans Degens

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Trends in Pharmacological Sciences
Alexander M Vaiserman, Francesco Marotta
Antioxidants & Redox Signaling
Vittorio Calabrese, Mahin D Maines
Gazette médicale de France
M JAMES
© 2022 Meta ULC. All rights reserved