Which Is the Most Significant Cause of Aging?

Antioxidants
Stefan I Liochev

Abstract

It becomes clearer and clearer that aging is a result of a significant number of causes and it would seem that counteracting one or several of them should not make a significant difference. Taken at face value, this suggests, for example, that free radicals and reactive oxygen species do not play a significant role in aging and that the lifespan of organisms cannot be significantly extended. In this review, I point to the fact that the causes of aging synergize with each other and discuss the implications involved. One implication is that when two or more synergizing causes increase over time, the result of their action increases dramatically; I discuss a simple model demonstrating this. It is reasonable to conclude that this might explain the acceleration of aging and mortality with age. In this regard, the analysis of results and mortality patterns described in studies involving yeasts and Drosophila provides support for this view. Since the causes of aging are synergizing, it is also concluded that none of them is the major one but many including free radicals, etc. play significant roles. It follows that health/lifespan might be significantly extended if we eliminate or even attenuate the increase of a few or even just one ...Continue Reading

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Citations

May 10, 2016·Pharmaceutical Biology·Augusto Faria AndradeDenise Crispim Tavares
Feb 9, 2017·Journal of Molecular Neuroscience : MN·Haiqin WuMeng Zhang
Mar 3, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Russel J ReiterBing Xu
Sep 2, 2021·Proceedings of the National Academy of Sciences of the United States of America·Federica De MajoLeon J De Windt

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