Which Orthopaedic Patients Are Infected with Gram-negative Non-fermenting Rods?

Journal of Bone and Joint Infection
Omid JameiIlker Uçkay

Abstract

Background : 1(st) and 2(nd) generation cephalosporins used for perioperative prophylaxis in orthopaedic surgery do not cover non-fermenting Gram-negative rods (NFR). Methods: Epidemiological cohort study of adult patients operated for orthopedic infections between 2004 and 2014 with perioperative cefuroxim or vancomycin prophylaxis. Exclusion of polyneuropathic ischemic foot infections and septic bursitis cases. Results: Of the total 1840 surgical procedures in the study, 430 grew Gram-negative pathogens (23%), of which 194 (11%) were due to NFR and 143 (8%) to Pseudomonas aeruginosa. Overall, 634 episodes (35%) involved orthopaedic implants (321 arthroplasties, 135 plates, 53 nails, and others). In multivariate analysis and group comparisons, especially preoperative antibiotic use (124/194 vs. 531/1456; p<0.01) was significantly associated with NFR. Conclusions: Overall proportion of NFR oscillated between 9% and 13% among our orthopaedic infections. Variables associated with NFR were antibiotic use prior to hospitalization. The low infection rate of NFR following elective surgery and the community-based epidemiology, has led us to keep our standard perioperative prophylaxis unchanged.

References

Oct 25, 2008·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Alicia I HidronUNKNOWN Participating National Healthcare Safety Network Facilities
Aug 21, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pang-Hsin HsiehSteve W Ueng
Feb 23, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ilker Uçkay, Louis Bernard
Sep 10, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C A AboltinsP A Stanley
Jun 7, 2011·The Journal of Arthroplasty·Benjamin ZmistowskiJavad Parvizi
Dec 8, 2011·Orthopedics·Andreas F MavrogenisPietro Ruggieri
Jan 21, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·P VergidisR R Razonable
Nov 14, 2012·International Journal of Antimicrobial Agents·Florent ValourUNKNOWN Colistin BJIs Study Group
Sep 21, 2013·International Orthopaedics·Mohamed Al-MayahiIlker Uçkay
Jan 28, 2015·Clinical Cancer Investigation Journal·Ilker UçkayPanayiotis Christofilopoulos
Sep 12, 2015·Infectious Diseases·Mohamed Al-MayahiIlker Uçkay

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Citations

Sep 9, 2019·Aging Clinical and Experimental Research·Ilker UçkayJan Burkhard
Nov 21, 2018·Antimicrobial Resistance and Infection Control·Marie DavatIlker Uçkay
Apr 23, 2019·Endocrinology, Diabetes & Metabolism·Anne RosselIlker Uçkay
May 21, 2019·The Journal of Antimicrobial Chemotherapy·Mohamed BenkaboucheIlker Uçkay
May 1, 2021·Medicina·Benjamin A Lipsky, İlker Uçkay
May 1, 2021·International Journal of Molecular Sciences·André BuschAndrea Sowislok

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