Abstract
Background : 1(st) and 2(nd) generation cephalosporins used for perioperative prophylaxis in orthopaedic surgery do not cover non-fermenting Gram-negative rods (NFR). Methods: Epidemiological cohort study of adult patients operated for orthopedic infections between 2004 and 2014 with perioperative cefuroxim or vancomycin prophylaxis. Exclusion of polyneuropathic ischemic foot infections and septic bursitis cases. Results: Of the total 1840 surgical procedures in the study, 430 grew Gram-negative pathogens (23%), of which 194 (11%) were due to NFR and 143 (8%) to Pseudomonas aeruginosa. Overall, 634 episodes (35%) involved orthopaedic implants (321 arthroplasties, 135 plates, 53 nails, and others). In multivariate analysis and group comparisons, especially preoperative antibiotic use (124/194 vs. 531/1456; p<0.01) was significantly associated with NFR. Conclusions: Overall proportion of NFR oscillated between 9% and 13% among our orthopaedic infections. Variables associated with NFR were antibiotic use prior to hospitalization. The low infection rate of NFR following elective surgery and the community-based epidemiology, has led us to keep our standard perioperative prophylaxis unchanged.
References
Mar 1, 1991·Antimicrobial Agents and Chemotherapy·T FeketeK R Cundy
Apr 18, 2007·Antimicrobial Agents and Chemotherapy·John Turnidge, Gerry Bordash
Dec 15, 2007·The Journal of Hospital Infection·I UçkayD Pittet
Oct 25, 2008·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Alicia I HidronUNKNOWN Participating National Healthcare Safety Network Facilities
Aug 19, 2009·Antimicrobial Agents and Chemotherapy·Juan C Martínez-PastorAlex Soriano
Aug 21, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pang-Hsin HsiehSteve W Ueng
Feb 23, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ilker Uçkay, Louis Bernard
Sep 10, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C A AboltinsP A Stanley
Mar 1, 2011·Annals of Medicine·Ilker UçkayDidier Pittet
Jun 7, 2011·The Journal of Arthroplasty·Benjamin ZmistowskiJavad Parvizi
Oct 11, 2011·International Orthopaedics·Khalid SeghrouchniIlker Uçkay
Dec 8, 2011·Orthopedics·Andreas F MavrogenisPietro Ruggieri
Jan 21, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·P VergidisR R Razonable
Nov 14, 2012·International Journal of Antimicrobial Agents·Florent ValourUNKNOWN Colistin BJIs Study Group
Feb 19, 2013·The Journal of Hospital Infection·I UçkayD Pittet
Mar 30, 2013·SpringerPlus·Americo AgostinhoIlker Uçkay
Sep 21, 2013·International Orthopaedics·Mohamed Al-MayahiIlker Uçkay
Apr 15, 2014·Infection·O BargiacchiF G De Rosa
Jun 22, 2014·International Orthopaedics·Amanda GonzalezIlker Uçkay
Jan 28, 2015·Clinical Cancer Investigation Journal·Ilker UçkayPanayiotis Christofilopoulos
Sep 12, 2015·Infectious Diseases·Mohamed Al-MayahiIlker Uçkay
Citations
Sep 13, 2017·Journal of Bone and Joint Infection·Parham SendiIlker Uçkay
Sep 9, 2019·Aging Clinical and Experimental Research·Ilker UçkayJan Burkhard
Sep 7, 2018·JCI Insight·John M ThompsonLloyd S Miller
Jan 24, 2020·International Journal of Environmental Research and Public Health·Mark L VickersBenjamin Parkinson
Nov 21, 2018·Antimicrobial Resistance and Infection Control·Marie DavatIlker Uçkay
Apr 23, 2019·Endocrinology, Diabetes & Metabolism·Anne RosselIlker Uçkay
May 21, 2019·The Journal of Antimicrobial Chemotherapy·Mohamed BenkaboucheIlker Uçkay
Apr 16, 2021·Endocrinology, Diabetes & Metabolism·Ilker UçkayMartin C Berli
May 1, 2021·Medicina·Benjamin A Lipsky, İlker Uçkay
May 1, 2021·International Journal of Molecular Sciences·André BuschAndrea Sowislok