Which progenitor is the target cell in the development of acute promyelocytic leukemia?

Leukemia & Lymphoma
H TakatsukiH Nawata

Abstract

Acute promyelocytic leukemia (APL) is characterized by the t(15;17) which involves the PML gene and the retinoic acid receptor alpha (RAR alpha) gene, and the subsequent PML/RAR alpha fusion gene is a key event in the leukemogenesis of APL. We found that the PML/RAR alpha fusion gene was expressed in both granulocytic/macrophage and erythroid colonies in a few patients with APL. In some instances of acute myelogenous leukemia (AML), erythrocytes or platelets also expressed the glucose-6-phosphate dehydrogenase (G-6-PD) isoenzymes which were detected in the leukemic cells. Some APL cells show basophilic and monocytoid differentiation and these findings suggest that the leukemic precursor of APL is derived from a more primitive cell stage than the promyelocyte. The precursor cells appear to be derived from heterogeneous levels.

References

Dec 1, 1991·The Journal of Clinical Investigation·C ChomienneL Degos
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M AlcalayF Lo Coco
May 26, 1991·The New England Journal of Medicine·R P WarrellA Jakubowski
Aug 20, 1987·The New England Journal of Medicine·P J FialkowR Veith

❮ Previous
Next ❯

Citations

May 7, 1998·The International Journal of Biochemistry & Cell Biology·S Tenbaum, A Baniahmad
Feb 16, 2000·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·S J McKenna

❮ Previous
Next ❯

Related Concepts

Related Feeds

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.