Which Spreading Depolarizations Are Deleterious To Brain Tissue?

Neurocritical Care
C William ShuttleworthJed A Hartings

Abstract

Spreading depolarizations (SDs) are profound disruptions of cellular homeostasis that slowly propagate through gray matter and present an extraordinary metabolic challenge to brain tissue. Recent work has shown that SDs occur commonly in human patients in the neurointensive care setting and have established a compelling case for their importance in the pathophysiology of acute brain injury. The International Conference on Spreading Depolarizations (iCSD) held in Boca Raton, Florida, in September of 2018 included a discussion session focused on the question of "Which SDs are deleterious to brain tissue?" iCSD is attended by investigators studying various animal species including invertebrates, in vivo and in vitro preparations, diseases of acute brain injury and migraine, computational modeling, and clinical brain injury, among other topics. The discussion included general agreement on many key issues, but also revealed divergent views on some topics that are relevant to the design of clinical interventions targeting SDs. A draft summary of viewpoints offered was then written by a multidisciplinary writing group of iCSD members, based on a transcript of the session. Feedback of all discussants was then formally collated, reviewe...Continue Reading

Citations

May 6, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Melika HosseiniYama Akbari
Feb 6, 2020·Journal of Neurophysiology·R Meldrum RobertsonR David Andrew
Apr 24, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kazutaka Sugimoto, David Y Chung
Sep 23, 2020·Neurocritical Care·Alexis N SimpkinsUNKNOWN Neurotherapeutics Symposium 2019
Jul 8, 2020·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Mathieu LevesqueChristian Iorio-Morin
Dec 17, 2020·Proceedings. Biological Sciences·Jessica CarringtonHeath A MacMillan
Jul 27, 2021·Current Neurology and Neuroscience Reports·Marcey L Osgood
Jun 29, 2021·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·R Meldrum Robertson, Rachel A Van Dusen

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