Which stages of thymoma benefit from adjuvant chemotherapy post-thymectomy?

Interactive Cardiovascular and Thoracic Surgery
Saina AttaranKaren Harrison-Phipps

Abstract

A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was 'Which stages of thymoma benefit from adjuvant chemotherapy post thymectomy?' Altogether more than 150 papers were found using the reported search, of which only eight represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated; these studies have mainly reported the survival and recurrence rates of post-thymectomy patients who received adjuvant radiotherapy or chemoradiotherapy, and adjuvant radiotherapy alone was only used in a small group of patients in these studies. We did not find any randomized controlled trials comparing adjuvant chemotherapy with chemo/radiotherapy and, due to a very small incidence of this tumour, it is unlikely to see any trials in future. Studies were mainly retrospective or institutional reports and showed that, despite the high sensitivity of this tumour to chemotherapy agents and the use of chemotherapy as one of the main treatment modalities in the advanced stages of thymoma, current data are not supporting postoperative chemothera...Continue Reading

References

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Citations

Feb 24, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Giuseppe CardilloFilippo Lococo
Sep 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N GirardUNKNOWN ESMO Guidelines Committee
Dec 17, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Enrico RuffiniUNKNOWN European Society of Thoracic Surgeons Thymic Working Group
Dec 17, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Masatsugu Hamaji
Jun 3, 2014·Asian Cardiovascular & Thoracic Annals·Masatsugu HamajiHiroshi Date
Oct 18, 2015·World Journal of Surgical Oncology·Joerg LindenmannFreyja Maria Smolle-Juettner
Aug 15, 2020·World Journal of Surgical Oncology·Marius KemperKai Bachmann
Dec 28, 2016·Current Opinion in Oncology·Nicolas Girard, Claire Merveilleux du Vignaux
Nov 19, 2021·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Marcin Zielinski

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