Which visual functions depend on intermediate visual regions? Insights from a case of developmental visual form agnosia

Neuropsychologia
Sharon Gilaie-Dotan

Abstract

A key question in visual neuroscience is the causal link between specific brain areas and perceptual functions; which regions are necessary for which visual functions? While the contribution of primary visual cortex and high-level visual regions to visual perception has been extensively investigated, the contribution of intermediate visual areas (e.g. V2/V3) to visual processes remains unclear. Here I review more than 20 visual functions (early, mid, and high-level) of LG, a developmental visual agnosic and prosopagnosic young adult, whose intermediate visual regions function in a significantly abnormal fashion as revealed through extensive fMRI and ERP investigations. While expectedly, some of LG's visual functions are significantly impaired, some of his visual functions are surprisingly normal (e.g. stereopsis, color, reading, biological motion). During the period of eight-year testing described here, LG trained on a perceptual learning paradigm that was successful in improving some but not all of his visual functions. Following LG's visual performance and taking into account additional findings in the field, I propose a framework for how different visual areas contribute to different visual functions, with an emphasis on int...Continue Reading

References

Jun 4, 1979·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A Cowey, J Porter
Jan 1, 1991·Cerebral Cortex·D J Felleman, D C Van Essen
May 1, 1988·Trends in Neurosciences·E A DeYoe, D C Van Essen
Sep 1, 1989·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·A D Milner, Charles A Heywood
Jun 8, 1986·The Journal of Comparative Neurology·L G Ungerleider, R Desimone
Mar 1, 1968·The Journal of Physiology·D H Hubel, T N Wiesel
Jun 1, 1983·Brain : a Journal of Neurology·J ZihlN Mai
Jan 1, 1983·Gerontology·A C Hooper
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·Rafael MalachR B Tootell
Sep 8, 1994·Nature·E A DeYoeE McClendon
Jun 1, 1996·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·R Ariel, M Sadeh
Apr 1, 1997·Brain and Cognition·M GrossmanMark D'Esposito
May 22, 1997·Nature·Merav Ahissar, Shaul Hochstein
Apr 29, 1998·Nature·R Epstein, N Kanwisher
Aug 26, 1998·Nature·Gregory C DeAngelisW T Newsome
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·P JanssenGuy A Orban
Jun 6, 2000·Neuropsychologia·M S BeauchampE A DeYoe
Oct 31, 2000·Journal of Cognitive Neuroscience·E GrossmanR Blake
Nov 14, 2000·Trends in Neurosciences·V A Lamme, P R Roelfsema
Mar 30, 2001·Cerebral Cortex·Y LernerRafael Malach
Dec 12, 2001·Cerebral Cortex·Y LernerRafael Malach
Feb 9, 2002·Human Brain Mapping·Sharon Gilaie-DotanRafael Malach
Mar 26, 2002·Trends in Cognitive Sciences·Rafael MalachUri Hasson
Dec 7, 2002·Neuron·Shaul Hochstein, Merav Ahissar
Apr 3, 2003·Journal of Experimental Psychology. Human Perception and Performance·Marlene Behrmann, Ruth Kimchi
Aug 26, 2003·Nature Neuroscience·Ione FineDonald I A MacLeod
Apr 15, 2004·Human Brain Mapping·Ifat LevyRafael Malach
Apr 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Uri PolatD Sagi
Jun 26, 2004·Annual Review of Neuroscience·Kalanit Grill-Spector, Rafael Malach
Sep 21, 2004·Nature Neuroscience·Lawrence C SincichJonathan C Horton
Jan 1, 1950·The Journal of Nervous and Mental Disease·A ADLER
Oct 16, 2004·Vision Research·Yoram BonnehUri Polat
Feb 11, 2005·Cerebral Cortex·Juha SilvantoVincent Walsh
Apr 29, 2005·Cerebral Cortex·Seth E Bouvier, Stephen A Engel
Aug 17, 2005·Journal of Cognitive Neuroscience·Galia AvidanMarlene Behrmann
Jul 31, 2007·Brain : a Journal of Neurology·Ayse Pinar Saygin
Aug 28, 2007·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Eileen BirchRussell Adams
Nov 3, 2007·NeuroImage·Serge O Dumoulin, Brian A Wandell
Nov 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anna W RoeGregory C DeAngelis
Nov 9, 2007·Neuron·Bevil R ConwayDoris Y Tsao
Dec 7, 2007·NeuroImage·Sharon Gilaie-DotanRafael Malach
Sep 13, 2008·Current Biology : CB·Lotte MeteyardGabriella Vigliocco
Oct 10, 2008·Journal of Vision·Jedediah M Singer, David L Sheinberg
Nov 26, 2008·Nature Neuroscience·Cibu ThomasMarlene Behrmann
Jan 23, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Svetlana GeorgievaGuy A Orban
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Bevil R Conway, Doris Y Tsao
Nov 7, 2009·Psychological Science·Yuri OstrovskyPawan Sinha
May 4, 2010·Attention, Perception & Psychophysics·Joseph L BrooksJon Driver
Jan 18, 2011·Neuropsychologia·Sharon Gilaie-DotanAyse Pinar Saygin
Apr 13, 2011·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Hillel AviezerShlomo Bentin
Apr 26, 2011·Cerebral Cortex·Taihei NinomiyaMasahiko Takada
Jul 13, 2011·Neuron·Christina S KonenSabine Kastner
Jan 24, 2012·Journal of Cognitive Neuroscience·Bianca Michelle van KemenadeAyse Pinar Saygin
Sep 29, 2012·Neuropsychologia·Mohamed L SeghierCathy J Price
Dec 6, 2012·Neuropsychologia·Sharon Gilaie-DotanAyse Pinar Saygin
Oct 1, 1997·Journal of Cognitive Neuroscience·G McCarthyT Allison
Aug 29, 2013·Brain : a Journal of Neurology·Sharon Gilaie-DotanMarlene Behrmann
Oct 22, 2013·Nature Neuroscience·Rosa Lafer-Sousa, Bevil R Conway
May 8, 2014·Cognitive Neuropsychology·Thomas HabekostRandi Starrfelt
Oct 15, 2014·Journal of Cognitive Neuroscience·Tirta SusiloBradley Duchaine
Dec 3, 2014·Trends in Neurosciences·Juha Silvanto
Jan 8, 2015·Frontiers in Computational Neuroscience·Jonas KubiliusHans P Op de Beeck
Jan 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Sharon Gilaie-DotanMarlene Behrmann
Mar 6, 2015·Frontiers in Integrative Neuroscience·Josef Zihl, Charles A Heywood

Citations

Feb 2, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Erez FreudSharon Gilaie-Dotan
Jan 14, 2018·Scientific Reports·Benjamin de Haas, Dietrich Samuel Schwarzkopf

Related Concepts

Agnosia for Temperature
Functional Cerebral Localization
Electroencephalogram
Visual Evoked Cortical Potential
Optical Image Reconstruction
Magnetization Transfer Contrast Imaging
Dioxygen
Photic Stimulation
Visual Cortex
Visual Perception

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.