Whiplash-like facet joint loading initiates glutamatergic responses in the DRG and spinal cord associated with behavioral hypersensitivity.

Brain Research
Ling DongB A Winkelstein

Abstract

The cervical facet joint and its capsule are a common source of neck pain from whiplash. Mechanical hyperalgesia elicited by painful facet joint distraction is associated with spinal neuronal hyperexcitability that can be induced by transmitter/receptor systems that potentiate the synaptic activation of neurons. This study investigated the temporal response of a glutamate receptor and transporters in the dorsal root ganglia (DRG) and spinal cord. Bilateral C6/C7 facet joint distractions were imposed in the rat either to produce behavioral sensitivity or without inducing any sensitivity. Neuronal metabotropic glutamate receptor-5 (mGluR5) and protein kinase C-epsilon (PKCε) expression in the DRG and spinal cord were evaluated on days 1 and 7. Spinal expression of a glutamate transporter, excitatory amino acid carrier 1 (EAAC1), was also quantified at both time points. Painful distraction produced immediate behavioral hypersensitivity that was sustained for 7 days. Increased expression of mGluR5 and PKCε in the DRG was not evident until day 7 and only following painful distraction; this increase was observed in small-diameter neurons. Only painful facet joint distraction produced a significant increase (p<0.001) in neuronal mGluR...Continue Reading

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Citations

Oct 1, 2013·Traffic Injury Prevention·N GalesS Schick
Jun 17, 2014·Expert Opinion on Pharmacotherapy·Jo NijsMira Meeus
Jan 29, 2016·Journal of the Royal Society, Interface·Sijia ZhangBeth A Winkelstein
Jan 7, 2014·The Journal of Pain : Official Journal of the American Pain Society·Christine L Weisshaar, Beth A Winkelstein
Oct 22, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Ashley Dean SmithMichele Sterling
Apr 29, 2015·Clinical Orthopaedics and Related Research·Martha E ZeemanBeth A Winkelstein
Mar 26, 2013·Neuroscience Letters·Nathan D CrosbyBeth A Winkelstein
Jul 2, 2017·The Journal of Orthopaedic and Sports Physical Therapy·James M Elliott, David M Walton
Jun 18, 2017·The Journal of Orthopaedic and Sports Physical Therapy·Meagan E ItaBeth A Winkelstein
Sep 20, 2017·Annals of Biomedical Engineering·Sijia ZhangBeth A Winkelstein
Feb 28, 2017·Journal of Biomechanical Engineering·Ehsan BanCatalin R Picu
Jan 6, 2017·Journal of Biomechanical Engineering·Megan M SperryBeth Winkelstein
Nov 20, 2018·Computer Methods in Biomechanics and Biomedical Engineering·Victor W L ChanCatalin R Picu
Jul 20, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Sijia ZhangBeth A Winkelstein
Nov 13, 2017·ACS Biomaterials Science & Engineering·Sijia ZhangBeth A Winkelstein

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