PMID: 16524545Mar 10, 2006Paper

Whipple's Disease

Current Infectious Disease Reports
Klaus MönkemüllerPeter Malfertheiner

Abstract

Whipple's disease (WD) is a chronic debilitating disease caused by the bacillus Tropheryma whippleii. WD classically presents with the main clinical symptoms of polyarthralgias, chronic diarrhea, weight loss, and abdominal pain. Given its systemic involvement, it is common for WD to present with a multitude of other clinical scenarios--sometimes with predominant neurologic, cardiac, and dermatologic manifestations. WD can occur at any age, but it generally occurs during the fifth decade and predominantly in men. The diagnosis of WD is established by demonstrating the organism on biopsies from the involved system, by histology, electron microscopy, polymerase chain reaction, and more recently, by culture of bacteria. The histologic features include a coarse granular cytoplasm and foamy macrophages that stain strongly with the period-acid Schiff reagent. Current therapy includes an initial 2-week course of intravenous cephalosporins followed by 1-year oral trimethoprim-sulfamethoxazole.

References

Jul 1, 1975·Acta Medica Scandinavica·L ElsborgN O Jacobsen
Oct 1, 1979·European Journal of Clinical Investigation·G E FeurleV Lenhard
Jul 30, 1992·The New England Journal of Medicine·D A RelmanS Falkow
Aug 24, 1991·Lancet·K H WilsonJ A Wilson
Jan 1, 1973·Seminars in Arthritis and Rheumatism·M E LeVine, W O Dobbins
Oct 1, 1996·Annals of Neurology·E D LouisJ Odel
Jan 1, 1997·Scandinavian Journal of Gastroenterology·A von HerbayM Maiwald
Apr 1, 1997·Annals of Internal Medicine·N N RamzanD H Persing
Sep 18, 1997·The Journal of Infectious Diseases·G SchoedonA Schaffner
Jan 7, 1998·Human Pathology·M EckH K Müller-Hermelink
Feb 17, 1998·Applied and Environmental Microbiology·M MaiwaldA von Herbay
Apr 16, 1998·QJM : Monthly Journal of the Association of Physicians·S A MisbahN Mapstone
Dec 29, 1998·Annals of Internal Medicine·T SchneiderM Zeitz
Apr 7, 1999·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B PronP Berche
Oct 8, 1999·Lancet·S StreetG H Neild
Oct 21, 1999·Scandinavian Journal of Infectious Diseases·T SüzerB Cetin
Jan 12, 2000·Digestive Diseases and Sciences·D D DykmanW Strober
Mar 4, 2000·The New England Journal of Medicine·D RaoultT J Marrie
Nov 7, 2000·Journal of Clinical Pathology·S A Misbah, N P Mapstone
Jul 4, 2001·Clinical Microbiology Reviews·F Dutly, M Altwegg
Aug 9, 2001·International Journal of Systematic and Evolutionary Microbiology·B La ScolaD Raoult
Oct 31, 2002·Gastroenterology·Thomas MarthThomas Schneider
Jan 28, 2003·Lancet·Thomas Marth, Didier Raoult
Sep 10, 2003·Current Gastroenterology Reports·Florence Fenollar, Didier Raoult
Mar 27, 2004·Gastrointestinal Endoscopy·Lucía C FryKlaus E Mönkemüller
Oct 12, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Julio C BaiEduardo Mauriño
Dec 16, 2004·Clinical and Experimental Medicine·R Mahnel, T Marth

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Citations

Nov 26, 2019·European Journal of Gastroenterology & Hepatology·Laurence FerrieresLaurent Alric
Jan 6, 2007·Histopathology·S R Owens, J K Greenson
Jun 26, 2008·Digestion·Klaus MönkemüllerPeter Malfertheiner

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