White and blue light induce reduction in susceptibility to minocycline and tigecycline in Acinetobacter spp. and other bacteria of clinical importance

Journal of Medical Microbiology
María Soledad RamírezMaría Alejandra Mussi

Abstract

Minocycline (MIN) and tigecycline (TIG) are antibiotics currently used for treatment of multidrug-resistant nosocomial pathogens. In this work, we show that blue light, as well as white light, modulates susceptibility to these antibiotics in a temperature-dependent manner. The modulation of susceptibility by light depends on the content of iron; an increase in iron results in a reduction in antibiotic susceptibility both under light and in the dark, though the effect is more pronounced in the latter condition. We further provide insights into the mechanism by showing that reduction in susceptibility to MIN and TIG induced by light is likely triggered by the generation of (1)O2, which, by a yet unknown mechanism, would ultimately lead to the activation of resistance genes such as those coding for the efflux pump AdeABC. The clinical relevance of these results may lie in surface-exposed wound infections, given the exposure to light in addition to the relatively low temperatures recorded in this type of lesion. We further show that the modulation of antibiotic susceptibility occurs not only in Acinetobacter baumannii but also in other micro-organisms of clinical relevance such as Escherichia coli and Staphylococcus aureus. Overall...Continue Reading

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Citations

Jul 23, 2016·Photodiagnosis and Photodynamic Therapy·Maryam PourhajibagherAbbas Bahador
May 14, 2017·Photochemistry and Photobiology·Inés AbatedagaClaudio D Borsarelli
Mar 16, 2017·Journal of Bacteriology·Gabriela L MüllerMaría Alejandra Mussi
Jun 9, 2016·Antimicrobial Agents and Chemotherapy·German Matias TragliaMaria Soledad Ramirez
Jul 11, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Alejandro PezzaMaría A Mussi
Oct 28, 2017·The Journal of Microbiology·Bora Shin, Woojun Park
Jun 6, 2018·Frontiers in Microbiology·Agata Wozniak, Mariusz Grinholc
Jan 23, 2019·Frontiers in Microbiology·Viviana CafisoStefania Stefani
Nov 18, 2017·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Yucheng WangTianhong Dai
Jun 30, 2021·Scientific Reports·Marisel Romina TuttobeneMaría Alejandra Mussi

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