White and Gray Matter Abnormalities in Manifest Huntington's Disease: Cross-Sectional and Longitudinal Analysis

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
Wafaa SweidanEdwin George

Abstract

Early white matter (WM) changes and cortical atrophy in Huntington's disease (HD) are often evident before disease onset and extend through the brain during manifest stages. The trajectory of these brain abnormalities in symptomatic stages remains relatively unexplored. The aim of this study is to investigate how the pattern of WM and gray matter (GM) alterations progress over time. We investigated alterations in brain WM, cortical thickness, and subcortical structures using diffusion and structural magnetic resonance imaging, in manifest HD patients (n = 13) compared to age-matched healthy controls (n = 11). Imaging and clinical data for the HD group were collected at follow-up (7 months) to explore possible longitudinal changes. Cross-sectional analyses identified significant posterior cortical thinning (P < .05) and symmetric fractional anisotropy (FA) reduction (P < .01) in brain WM of HD group compared to HC. These changes were strongly correlated with impairment in motor symptoms and processing speed. Subcortical atrophy was significant in caudate, putamen, globus pallidus, and thalamus (P < .001). Regions of interest analysis revealed a significant reduction in FA of the corpus callosum (CC) (-2.19%, P < .05) upon follow...Continue Reading

References

Mar 1, 1994·Journal of Magnetic Resonance. Series B·P J BasserD LeBihan
Mar 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society
Dec 18, 2001·Human Brain Mapping·Thomas E Nichols, Andrew P Holmes
Apr 9, 2005·Journal of the American Geriatrics Society·Ziad S NasreddineHoward Chertkow
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Mar 14, 2008·Brain : a Journal of Neurology·H Diana RosasSteven M Hersch
Mar 26, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alexander Leemans, Derek K Jones
Oct 6, 2010·Neuropsychology·Julie C StoutElizabeth H Aylward
Jan 18, 2012·NeuroImage·Bruce Fischl
Apr 5, 2014·Human Brain Mapping·Tara MadhyasthaLutz Jäncke
Dec 17, 2014·Neurobiology of Disease·Govinda R PoudelNellie Georgiou-Karistianis

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Citations

Sep 27, 2020·Brain and Behavior·Beatrice HeimAtbin Djamshidian
Oct 10, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Carlos Estevez-FragaSarah Gregory

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