White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner

Gastroenterology Research and Practice
Lanyun FengLuming Liu

Abstract

Pancreatic cancer is associated with high death rates and limited therapeutic options, with no effective predictive factors being available for prognosis at present. In this study, we evaluate the value of using blood test results for pancreatic cancer prognosis. The records of 214 pancreatic cancer patients were reviewed. Blood test results for white blood cell (WBC), granulocyte, neutrophil, lymphocyte, platelet count, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were dichotomized on the basis of median values. This was followed by univariate and multivariate analyses between groups. Patients with pretreatment values in the range WBC ≥ 5.8 × 109/L, granulocyte ≥ 3.7 × 109/L, neutrophil ≥ 3.9 × 109/L, lymphocyte < 1.4 × 109/L, and NLR ≥ 2.8 showed significant correlations pointing to poorer overall survival. Multivariate analysis indicated that WBC ≥ 5.8 × 109/L (HR = 1.808; 95% CI = 1.055-3.096; p = 0.031) and granulocyte ≥ 3.7 × 109/L (HR = 7.346; 95% CI = 1.275-42.321; p = 0.026) can be taken to be independent prognostic factors for overall survival in pancreatic patients. Pretreatment values of WBC and granulocyte count were independent factors with poor prognosis ability with respect to pan...Continue Reading

References

Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Dec 22, 2007·Nature Reviews. Immunology·Laurence ZitvogelGuido Kroemer
Jul 25, 2008·Nature·Alberto MantovaniFrances Balkwill
Sep 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hanne Krogh JensenHans von der Maase
Mar 12, 2010·Nature·Massimo AmmiranteMichael Karin
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Jun 28, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Eun Jin YooYong Chan Lee
Oct 5, 2014·The Lancet Oncology·Connie I DiakosStephen J Clarke
Mar 12, 2015·World Journal of Gastroenterology : WJG·Jian-Jun YangSheng-Guang Yuan
May 7, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Rou JiangMing-Yuan Chen
Sep 13, 2015·Clinical Lymphoma, Myeloma & Leukemia·Hugo J A AdamsThomas C Kwee
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Feb 27, 2016·International Journal of Cancer. Journal International Du Cancer·Qing-Tao ZhaoGuo-Chen Duan
Aug 23, 2017·Cancer Letters·Mengyu FengYupei Zhao

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

Prism GraphPad
SPSS

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.