White Blood Cells and Blood Pressure: A Mendelian Randomization Study.

Circulation
Mateusz SiedlinskiTomasz J Guzik

Abstract

High blood pressure (BP) is a risk factor for cardiovascular morbidity and mortality. While BP is regulated by the function of kidney, vasculature, and sympathetic nervous system, recent experimental data suggest that immune cells may play a role in hypertension. We studied the relationship between major white blood cell types and blood pressure in the UK Biobank population and used Mendelian randomization (MR) analyses using the ≈750 000 UK-Biobank/International Consortium of Blood Pressure-Genome-Wide Association Studies to examine which leukocyte populations may be causally linked to BP. A positive association between quintiles of lymphocyte, monocyte, and neutrophil counts, and increased systolic BP, diastolic BP, and pulse pressure was observed (eg, adjusted systolic BP mean±SE for 1st versus 5th quintile respectively: 140.13±0.08 versus 141.62±0.07 mm Hg for lymphocyte, 139.51±0.08 versus 141.84±0.07 mm Hg for monocyte, and 137.96±0.08 versus 142.71±0.07 mm Hg for neutrophil counts; all P<10-50). Using 121 single nucleotide polymorphisms in MR, implemented through the inverse-variance weighted approach, we identified a potential causal relationship of lymphocyte count with systolic BP and diastolic BP (causal estimates: 0...Continue Reading

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Citations

Jan 5, 2021·Cell and Tissue Research·Ulrich O WenzelMarlies Bode
Oct 29, 2020·Annals of Cardiac Anaesthesia·Amit Rastogi, Prabhat Tewari
Jan 26, 2021·International Journal of Hypertension·Alexander KamyshnyiOleh Lushchak
Nov 18, 2020·International Journal of Molecular Sciences·Patricio AraosCristián A Amador
Apr 2, 2021·Circulation Research·Carmine SavoiaReinhold Kreutz
Apr 4, 2021·Journal of Personalized Medicine·Yitang SunKaixiong Ye
May 22, 2021·Journal of Complementary & Integrative Medicine·Olayinka Ayotunde OridupaTemidayo Olutayo Omobowale
Jun 1, 2021·Clinical Hemorheology and Microcirculation·Maria FornalTomasz Grodzicki
Jun 22, 2021·Hypertension·Tomasz J Guzik, Marta Czesnikiewicz-Guzik
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Aug 28, 2021·Journal of Clinical Medicine·Tiziana CiarambinoMaria D'Avino
Sep 19, 2021·Journal of Human Hypertension·Doreen BusingyeAmanda G Thrift
Aug 12, 2021·British Journal of Pharmacology·Neil MacRitchiePasquale Maffia

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Software Mentioned

PRESSO [ Mendelian Randomization Pleiotropy Residual Sum and O...
TwoSampleMR
quantreg
MendelianRandomization
mgcv
- Pleiotropy Residual
SPSS
IVW
PRESSO
- PRESSO [ Mendelian Randomization Pleiotropy Residual Sum and...

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