White light polarization sensitive optical coherence tomography for sub-micron axial resolution and spectroscopic contrast in the murine retina

Biomedical Optics Express
Danielle J HarperBernhard Baumann

Abstract

A white light polarization sensitive optical coherence tomography system has been developed, using a supercontinuum laser as the light source. By detecting backscattered light from 400 - 700 nm, an axial resolution of 1.0 µm in air was achieved. The system consists of a free-space interferometer and two homemade spectrometers that detect orthogonal polarization states. Following system specifications, images of a healthy murine retina as acquired by this non-contact system are presented, showing high resolution reflectivity images as well as spectroscopic and polarization sensitive contrast. Additional images of the very-low-density-lipoprotein-receptor (VLDLR) knockout mouse model were acquired. The high resolution allows the detection of small lesions in the retina.

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Citations

Dec 12, 2018·Journal of Biological Engineering·Maryse Lapierre-LandryMelissa C Skala
Jul 2, 2019·Biomedical Optics Express·Tingwei ZhangVivek J Srinivasan
May 3, 2019·Optics Express·Rasmus Dybbro Engelsholm, Ole Bang
Aug 21, 2020·Translational Vision Science & Technology·Marco AugustinBernhard Baumann
Feb 16, 2019·Optics Letters·Aaron Kho, Vivek J Srinivasan
Jun 30, 2021·Light, Science & Applications·Shreesha Rao D SOle Bang

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