White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging

Scientific Reports
Siren TønnesenLars Tjelta Westlye

Abstract

Supported by histological and genetic evidence implicating myelin, neuroinflammation and oligodendrocyte dysfunction in schizophrenia spectrum disorders (SZ), diffusion tensor imaging (DTI) studies have consistently shown white matter (WM) abnormalities when compared to healthy controls (HC). The diagnostic specificity remains unclear, with bipolar disorders (BD) frequently conceptualized as a less severe clinical manifestation along a psychotic spectrum. Further, the age-related dynamics and possible sex differences of WM abnormalities in SZ and BD are currently understudied. Using tract-based spatial statistics (TBSS) we compared DTI-based microstructural indices between SZ (n = 128), BD (n = 61), and HC (n = 293). We tested for age-by-group and sex-by-group interactions, computed effect sizes within different age-bins and within genders. TBSS revealed global reductions in fractional anisotropy (FA) and increases in radial (RD) diffusivity in SZ compared to HC, with strongest effects in the body and splenium of the corpus callosum, and lower FA in SZ compared to BD in right inferior longitudinal fasciculus and right inferior fronto-occipital fasciculus, and no significant differences between BD and HC. The results were not st...Continue Reading

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Citations

Jan 30, 2019·European Archives of Psychiatry and Clinical Neuroscience·Natalia TesliUnn K Haukvik
Mar 16, 2019·Scientific Reports·Philipp StämpfliMatthias Kirschner
Nov 13, 2019·Proceedings of the National Academy of Sciences of the United States of America·Stefano BertoGenevieve Konopka
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Dec 7, 2019·Brain Research·Mohammed A Mostajo-RadjiAlex A Pollen
May 1, 2020·Trends in Neurosciences·Katherine H Karlsgodt
Nov 15, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sung Woo JooJungsun Lee
Jun 11, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sung Woo JooJungsun Lee
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Software Mentioned

TBSS
Eddy
DTIPrep
MAXVOX
FSL
ENIGMA
R
LOESS
boot package
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