Nov 11, 2019

White matter burden does not influence the outcome of mechanical thrombectomy

Journal of Neurology
Laura MechtouffTae-Hee Cho


The significance of white matter hyperintensities (WMHs) in the setting of mechanical thrombectomy (MT) remains poorly documented. We assessed whether pre-existing WMHs burden was associated with baseline clinical and imaging factors and neurological outcome in patients undergoing MT. This retrospective single-center study included consecutive acute ischemic stroke (AIS) patients with stroke due to large vessel occlusion treated with MT. WMHs were assessed on baseline T2 fluid-attenuated inversion recovery magnetic resonance imaging. Neurological outcome was assessed at day 90 by the modified Rankin Scale (mRS). We analyzed the association between WMH burden and clinical and imaging factors by univariate and multivariate logistic regression analyses. Between July 2013 and June 2019, 293 patients with anterior circulation AIS met the inclusion criteria. WMHs burden was not associated to baseline NIHSS score severity (OR 0.89, 95% CI 0.54-1.49, p = 0.66), poor collateral status, Higashida score < 3 (OR 1.5 95% CI 0.62-3.56, p = 0.36), higher DWI volume (OR 0.69, 95% CI 0.41-1.15, p = 0.16) or to a lower recanalization rate, TICI 0/2a (OR 0.98 95% CI 0.56-1.69, p = 0.95). WMHs severity did not influence the risk of parenchymal hem...Continue Reading

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Mentioned in this Paper

Vessels; Occlusion
Univariate Analysis
Magnetic Resonance Imaging
Diffusion Weighted Imaging
Cerebrovascular Accident
Measles-rubella vaccine (live)
Modified Rankin Scale

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