White matter changes associated with cognitive visual dysfunctions in children with cerebral palsy: A diffusion tensor imaging study

Journal of Neuroscience Research
Jessica GalliElisa Fazzi

Abstract

Children with cerebral palsy often present with cognitive-visual dysfunctions characterized by visuo-perceptual and/or visuo-spatial deficits associated with a malfunctioning of visual-associative areas. The neurofunctional model of this condition remains poorly understood due to the lack of a clear correlation between cognitive-visual deficit and morphological brain anomalies. The aim of our study was to quantify the pattern of white matter abnormalities within the whole brain in children with cerebral palsy, and to identify white matter tracts sub-serving cognitive-visual functions, in order to better understand the basis of cognitive-visual processing. Nine subjects (three males, mean age 8 years 9 months) with cerebral palsy underwent a visual and cognitive-visual evaluation. Conventional brain MRI and diffusion tensor imaging were performed. The fractional anisotropy maps were calculated for every child and compared with data from 13 (four males, mean age 10 years 7 months) healthy children. Children with cerebral palsy showed decreased fractional anisotropy (a marker of white matter integrity) in corticospinal tract bilaterally, left superior longitudinal fasciculus and bilateral hippocampus. Focusing on the superior long...Continue Reading

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Citations

Apr 22, 2020·Developmental Medicine and Child Neurology·Lena JacobsonMaria Nilsson
Nov 30, 2019·Frontiers in Human Neuroscience·Claudio MaioliElisa M Fazzi
Feb 1, 2020·Research in Developmental Disabilities·Swetha Sara PhilipRoslyn N Boyd
Jul 16, 2021·Scientific Reports·Marina A PavlovaElisa M Fazzi
Jul 26, 2021·Indian Journal of Ophthalmology·Niranjan K Pehere, Gordon N Dutton
Feb 23, 2020·Annals of Physical and Rehabilitation Medicine·Joel Fluss, Karen Lidzba

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