White matter connectivity disruptions in early and chronic schizophrenia

Psychological Medicine
Maria A Di BiaseAndrew Zalesky

Abstract

White matter disruptions in schizophrenia have been widely reported, but it remains unclear whether these abnormalities differ between illness stages. We mapped the connectome in patients with recently diagnosed and chronic schizophrenia and investigated the extent and overlap of white matter connectivity disruptions between these illness stages. Diffusion-weighted magnetic resonance images were acquired in recent-onset (n = 19) and chronic patients (n = 45) with schizophrenia, as well as age-matched controls (n = 87). Whole-brain fiber tracking was performed to quantify the strength of white matter connections. Connections were tested for significant streamline count reductions in recent-onset and chronic groups, relative to separate age-matched controls. Permutation tests were used to assess whether disrupted connections significantly overlapped between chronic and recent-onset patients. Linear regression was performed to test whether connectivity was strongest in controls, weakest in chronic patients, and midway between these extremities in recent-onset patients (controls > recent-onset > chronic). Compared with controls, chronic patients displayed a widespread network of connectivity disruptions (p < 0.01). In contrast, con...Continue Reading

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Citations

Sep 27, 2018·Human Brain Mapping·Lena K L OestreichMarta I Garrido
Nov 9, 2018·Frontiers in Pharmacology·Candice E Crocker, Philip G Tibbo
Feb 28, 2018·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Avital PrielRuth Feldman
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Jun 6, 2019·The American Journal of Psychiatry·Cassandra M J WannanAndrew Zalesky
Sep 15, 2018·Schizophrenia Bulletin·Maria Angelique Di BiaseAndrew Zalesky
Feb 21, 2019·Psychological Medicine·Maria Angelique Di BiaseOfer Pasternak
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Apr 8, 2020·Journal of Psychiatry and Brain Science·Kathryn E LewandowskiMartha E Shenton
Aug 7, 2021·Psychiatry Research. Neuroimaging·Han-Yu ZhouRaymond C K Chan
Sep 25, 2021·European Archives of Psychiatry and Clinical Neuroscience·Cassandra M J WannanVanessa L Cropley

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