White matter damage and brain network alterations in concussed patients: a review of recent diffusion tensor imaging and resting-state functional connectivity data

Current Pain and Headache Reports
Catherine D Chong, Todd J Schwedt

Abstract

Over 2 million people are diagnosed with concussion each year in the USA, resulting in substantial individual and societal burdens. Although 'routine' clinical neuroimaging is useful for the diagnosis of more severe forms of traumatic brain injury, it is insensitive for detecting pathology associated with concussion. Diffusion tensor imaging (DTI) and blood-oxygenation-level-dependent (BOLD) resting-state functional connectivity magnetic resonance imaging (rs-fMRI) are techniques that allow for investigation of brain structural and functional connectivity patterns. DTI and rs-fMRI may be more sensitive than routine neuroimaging for detecting brain sequelae of concussion. This review summarizes recent DTI and rs-fMRI findings of altered structural and functional connectivity patterns in concussed patients.

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Citations

Mar 24, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Emerson M WickwireChristopher J Lettieri
Jul 20, 2016·Journal of Neurotrauma·Michael L AloscoRobert A Stern
Oct 21, 2016·Frontiers in Neurology·Svetlana A DambinovaAlexander A Potapov
Aug 1, 2018·Current Pain and Headache Reports·Jill C RauTodd J Schwedt
Nov 10, 2020·The Journal of Head Trauma Rehabilitation·Amy A HerroldTommi Raij
Aug 29, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jake R TennantW Richard Staines

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