White matter differences between healthy young ApoE4 carriers and non-carriers identified with tractography and support vector machines.

PloS One
Laurence O'DwyerHarald Hampel

Abstract

The apolipoprotein E4 (ApoE4) is an established risk factor for Alzheimer's disease (AD). Previous work has shown that this allele is associated with functional (fMRI) changes as well structural grey matter (GM) changes in healthy young, middle-aged and older subjects. Here, we assess the diffusion characteristics and the white matter (WM) tracts of healthy young (20-38 years) ApoE4 carriers and non-carriers. No significant differences in diffusion indices were found between young carriers (ApoE4+) and non-carriers (ApoE4-). There were also no significant differences between the groups in terms of normalised GM or WM volume. A feature selection algorithm (ReliefF) was used to select the most salient voxels from the diffusion data for subsequent classification with support vector machines (SVMs). SVMs were capable of classifying ApoE4 carrier and non-carrier groups with an extremely high level of accuracy. The top 500 voxels selected by ReliefF were then used as seeds for tractography which identified a WM network that included regions of the parietal lobe, the cingulum bundle and the dorsolateral frontal lobe. There was a non-significant decrease in volume of this WM network in the ApoE4 carrier group. Our results indicate that...Continue Reading

References

May 1, 1994·Nature Genetics·K OkuizumiS Naruse
Dec 1, 1996·Obstetrics and Gynecology·W L HolcombD J Mostello
Feb 1, 1997·Archives of General Psychiatry·J M GoldD R Weinberger
Jan 16, 1998·Journal of Behavioral Medicine·N RavajaL Keltikangas-Järvinen
Feb 26, 1998·Immunopharmacology·B R Lucchesi, K S Kilgore
Aug 26, 1998·Dementia and Geriatric Cognitive Disorders·E Englund
Dec 22, 1999·Neurobiology of Aging·C E Finch, R M Sapolsky
Apr 19, 2000·Journal of Cognitive Neuroscience·P A Reuter-LorenzR A Koeppe
May 17, 2000·Proceedings of the National Academy of Sciences of the United States of America·G W SmallM E Phelps
Aug 17, 2000·The New England Journal of Medicine·S Y BookheimerG W Small
May 15, 2001·Journal of Computer Assisted Tomography·S M SmithP M Matthews
Aug 23, 2001·Medical Image Analysis·M Jenkinson, S Smith
Dec 18, 2001·Human Brain Mapping·Thomas E Nichols, Andrew P Holmes
Apr 5, 2002·Psychology and Aging·Roberto Cabeza
May 16, 2002·Neuroscience Letters·Henrik ZetterbergKaj Blennow
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Dec 13, 2002·Brain : a Journal of Neurology·Alexa M MorcomMichael D Rugg
Dec 17, 2002·NeuroImage·Stephen M SmithNicola De Stefano
Sep 4, 2003·Annals of Neurology·Peter J NestorJohn R Hodges
Oct 31, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T E J BehrensS M Smith
Dec 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Eric M ReimanJohn Hardy
Apr 10, 2004·Bioinformatics·Eibe FrankIan H Witten
Jun 18, 2005·Neurobiology of Aging·An-Tao DuMichael W Weiner
Aug 2, 2005·Neuroreport·Jay NierenbergKelvin O Lim
Sep 27, 2005·Journal of Medical Genetics·J-C BecherJ Bell
Feb 21, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·J-C BecherB Wyatt
Mar 16, 2006·Brain : a Journal of Neurology·Johanna LindLars Nyberg

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Citations

Oct 8, 2014·Nature Reviews. Neurology·Michela PievaniGiovanni B Frisoni
Oct 19, 2013·Journal of the International Neuropsychological Society : JINS·S M Hadi Hosseini, Shelli R Kesler
Oct 27, 2012·BMC Medicine·Maciej J LazarczykPanteleimon Giannakopoulos
Nov 16, 2012·PloS One·Laurence O'DwyerHarald Hampel
May 28, 2017·Journal of Alzheimer's Disease : JAD·Chang-Ho YunRobert J Thomas

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

FNIRT
DTIFIT
ABI 7000
Matlab
WEKA
TBSS
HAROLD
ReliefF
FSL
SIENAX

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