White matter disruptions in patients with bipolar disorder

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Lucija AbramovicNeeltje E M van Haren

Abstract

Bipolar disorder (BD) patients show aberrant white matter microstructure compared to healthy controls but little is known about the relation with clinical characteristics. We therefore investigated the relation of white matter microstructure with the main pharmacological treatments as well its relation with IQ. Patients with BD (N = 257) and controls (N = 167) underwent diffusion tensor imaging (DTI) and comprehensive clinically assessments including IQ estimates. DTI images were analyzed using tract-based spatial statistics. Fractional anisotropy (FA) and Mean Diffusivity (MD) were determined. Patients had significantly lower FA and higher MD values throughout the white matter skeleton compared to controls. Within the BD patients, lithium use was associated with higher FA and lower MD. Antipsychotic medication use in the BD patients was not associated with FA but, in contrast to lithium, was associated with higher MD. IQ was significantly positively correlated with FA and negatively with MD in patients as well as in controls. In this large DTI study we found evidence for marked differences in FA and MD particularly in (but not restricted to) corpus callosum, between BD patients and controls. This effect was most pronounced in ...Continue Reading

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Citations

Oct 8, 2019·Psychological Medicine·Catharine E KrebsRoel A Ophoff
Oct 28, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ibrahim A AkkouhTimothy Hughes
Aug 23, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Pauline FavreUNKNOWN ENIGMA Bipolar Disorder Working Group
Jan 21, 2021·Scientific Reports·Arthur Dun Ping MakSing Lee
May 11, 2021·Nordic Journal of Psychiatry·José Carlos L Espanhol, Maria A Vieira-Coelho
May 29, 2021·International Journal of Bipolar Disorders·Riccardo GuglielmoGregor Hasler
Aug 20, 2021·Psychiatry Research. Neuroimaging·Vina M GoghariLouise Emsell

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