White matter hyperintensities among older adults are associated with futile increase in frontal activation and functional connectivity during spatial search

PloS One
Samuel N LockhartCharles DeCarli

Abstract

The mechanisms by which aging and other processes can affect the structure and function of brain networks are important to understanding normal age-related cognitive decline. Advancing age is known to be associated with various disease processes, including clinically asymptomatic vascular and inflammation processes that contribute to white matter structural alteration and potential injury. The effects of these processes on the function of distributed cognitive networks, however, are poorly understood. We hypothesized that the extent of magnetic resonance imaging white matter hyperintensities would be associated with visual attentional control in healthy aging, measured using a functional magnetic resonance imaging search task. We assessed cognitively healthy older adults with search tasks indexing processing speed and attentional control. Expanding upon previous research, older adults demonstrate activation across a frontal-parietal attentional control network. Further, greater white matter hyperintensity volume was associated with increased activation of a frontal network node independent of chronological age. Also consistent with previous research, greater white matter hyperintensity volume was associated with anatomically sp...Continue Reading

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Citations

Sep 27, 2015·Biochimica Et Biophysica Acta·Prashanthi Vemuri, David S Knopman
Apr 12, 2016·Cognitive Neurodynamics·Ling-Li ZengDewen Hu
May 6, 2016·Frontiers in Neuroscience·Anne-Katrin VellageNotger G Müller
Nov 28, 2015·Cephalalgia : an International Journal of Headache·Louise O'Hare, Paul B Hibbard
Mar 5, 2016·Postgraduate Medical Journal·Guendalina Bonifacio, Giovanna Zamboni
Dec 22, 2020·Journal of Magnetic Resonance Imaging : JMRI·Luca MelazziniMarina Codari
May 17, 2021·Seminars in Cell & Developmental Biology·Faith M GunningLindsay W Victoria
Sep 6, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Samuel N LockhartTimothy M Hughes

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