White matter hyperintensities and working memory: an explorative study

Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
Joukje M OostermanErik J A Scherder

Abstract

White matter hyperintensities (WMH) are commonly observed in elderly people and may have the most profound effect on executive functions, including working memory. Surprisingly, the Digit Span backward, a frequently employed working memory task, reveals no association with WMH. In the present study, it was investigated whether more detailed analyses of WMH variables and study sample selection are important when establishing a possible relationship between the Digit Span backward and WMH. To accomplish this, the Digit Span backward and additional working memory tests, WMH subscores, and cardiovascular risk factors were examined. The results revealed that performance on the Digit Span backward test is unrelated to WMH, whereas a relationship between other working memory tests and WMH was confirmed. Furthermore, a division between several white matter regions seems important; hyperintensities in the frontal deep white matter regions were the strongest predictor of working memory performance.

References

Apr 1, 1977·Perceptual and Motor Skills·D M Gronwall
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Mar 1, 1991·Stroke; a Journal of Cerebral Circulation·P A WolfW B Kannel
Jan 1, 1986·European Journal of Nuclear Medicine·S A JacksonR H Martin
Aug 1, 1987·Journal of Clinical and Experimental Neuropsychology·G J Larrabee
Jan 1, 1986·Biological cybernetics·A G Fleischer
Nov 1, 1986·The Quarterly Journal of Experimental Psychology. A, Human Experimental Psychology·A BaddeleyH Spinnler
Nov 1, 1995·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·T A Salthouse, E J Meinz
Nov 1, 1995·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·T R Cole
Jan 1, 1994·Stroke; a Journal of Cerebral Circulation·R B D'AgostinoW B Kannel
Oct 29, 1996·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D N Pandya, E H Yeterian
Apr 16, 1998·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·C T FerreiraY Agid
Dec 14, 2002·Annals of the New York Academy of Sciences·John T O'BrienGary A Ford
Feb 8, 2003·Stroke; a Journal of Cerebral Circulation·P KapellerUNKNOWN European Task Force of Age Related White Matter Changes
Aug 13, 2003·Journal of Clinical and Experimental Neuropsychology·Michael C DiehrUNKNOWN HIV Neurobehavioral Research Center Group
Jan 17, 2004·Stroke; a Journal of Cerebral Circulation·Merrill F EliasPhilip A Wolf
Jun 26, 2004·Stroke; a Journal of Cerebral Circulation·Tom JeerakathilCharles DeCarli
Jan 20, 2005·Reviews in the Neurosciences·Joukje M OostermanErik J A Scherder
Feb 16, 2005·Magma·B AudoinJ-P Ranjeva
Feb 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·P S SachdevA F Jorm
May 3, 2005·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Elena L Grigorenko
Sep 1, 2005·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Kara L Bopp, Paul Verhaeghen
Dec 6, 2005·Neuroscience·S Funahashi
Jan 28, 2006·Stroke; a Journal of Cerebral Circulation·Elisabeth C W van StraatenUNKNOWN LADIS Group
Mar 1, 2006·Neurology·I J DearyJ M Wardlaw

❮ Previous
Next ❯

Citations

Jun 22, 2012·International Psychogeriatrics·Joukje M OostermanRoy P C Kessels
Feb 18, 2016·Neuroradiology·Pierre ChapuisAlexandre Krainik
Sep 23, 2014·Journal of the Neurological Sciences·Rufus O AkinyemiRaj N Kalaria
Oct 19, 2010·Nitric Oxide : Biology and Chemistry·Tennille D PresleyGary D Miller
Jan 26, 2012·International Journal of Aging & Human Development·Joukje M OostermanAlbert Postma
Nov 5, 2010·Journal of the American Geriatrics Society·Jessica R L Warsch, Clinton B Wright
Jul 7, 2019·Brain Imaging and Behavior·Anna Brugulat-SerratUNKNOWN ALFA Study
Oct 1, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Jiao WangWeili Xu

❮ Previous
Next ❯

Software Mentioned

SPSS
PASAT

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.