White matter hyperintensities are associated with falls in older people with dementia

Brain Imaging and Behavior
Morag E TaylorJacqueline C T Close

Abstract

White Matter Hyperintensities (WMHs) are associated with impaired gait, balance and cognition and increased fall risk in cognitively healthy older people. However, few studies have examined such relationships in older people with dementia. Understanding the role of WMHs in falls may assist in developing effective fall prevention strategies. We investigated the relationship between baseline WMHs, cognitive and sensorimotor function and prospective falls in older people with dementia. Twenty-eight community-dwelling older people with mild-moderate dementia (MMSE 11-23; ACE-R < 83) underwent magnetic resonance imaging and assessment of sensorimotor and cognitive (global and processing speed) function at baseline. WMHs, were quantified using a fully automated segmentation toolbox, UBO Detector ( https://cheba.unsw.edu.au/group/neuroimaging-pipeline ). Falls were ascertained prospectively for 12-months using monthly calendars with the assistance of carers. The median age of the participants was 83 years (IQR 77-86); 36% were female; 21 (75%) fell during follow-up. Using Generalized Linear Models, larger volumes of total WMHs were found to be significantly associated with poorer global cognitive and sensorimotor function. Using modif...Continue Reading

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Citations

Mar 2, 2021·Frontiers in Neurology·Bin LiuJingping Shi
Feb 27, 2021·Translational Stroke Research·Peiyu HuangMinming Zhang
Aug 1, 2021·The European Journal of Neuroscience·Xiaojia TangYingzhu Chen
Mar 4, 2020·La Revue de médecine interne·A Garnier-CrussardP Krolak-Salmon

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Software Mentioned

SPSS
SPM12
UBO
DARTEL

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