White matter hyperintensities, hot flushes and estrogen--are they related?

Climacteric : the Journal of the International Menopause Society
Amos Pines

Abstract

White matter hyperintensities (WMH) are areas of high intensity observed in brain MRI scans. They are usually seen in normal aging but also in a number of neurological and psychiatric disorders. One of the underlying mechanisms is ischemia, expressed as small vessel disease. Since the volume of WMH may correlate with cognition, and an ongoing debate links postmenopausal hormone therapy with stroke and a decline in certain cognitive domains, several MRI studies have addressed this potential association. Two major randomized, placebo-controlled trials - WHIMS and KEEPS, the first including elderly women and the second recruiting recently menopausal women, did not demonstrate any safety concerns in this respect in hormone users.

Related Concepts

Related Feeds

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Related Papers

Climacteric : the Journal of the International Menopause Society
Amos Pines
Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Vincent MokStephen T C Wong
European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
I MakedonovB J MacIntosh
© 2021 Meta ULC. All rights reserved