White Matter Injury Susceptibility via Fiber Strain Evaluation Using Whole-Brain Tractography

Journal of Neurotrauma
Wei ZhaoSongbai Ji

Abstract

Microscale brain injury studies suggest axonal elongation as a potential mechanism for diffuse axonal injury (DAI). Recent studies have begun to incorporate white matter (WM) structural anisotropy in injury analysis, with initial evidence suggesting improved injury prediction performance. In this study, we further develop a tractography-based approach to analyze fiber strains along the entire lengths of fibers from voxel- or anatomically constrained whole-brain tractography. This technique potentially extends previous element- or voxel-based methods that instead utilize WM fiber orientations averaged from typically coarse elements or voxels. Perhaps more importantly, incorporating tractography-based axonal structural information enables assessment of the overall injury risks to functionally important neural pathways and the anatomical regions they connect, which is not possible with previous methods. A DAI susceptibility index was also established to quantify voxel-wise WM local structural integrity and tract-wise damage of individual neural pathways. This "graded" injury susceptibility potentially extends the commonly employed treatment of injury as a simple binary condition. As an illustration, we evaluate the DAI susceptibil...Continue Reading

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Citations

Aug 25, 2016·Frontiers in Systems Neuroscience·Erin D Bigler
Sep 21, 2016·Biomechanics and Modeling in Mechanobiology·Wei Zhao, Songbai Ji
Aug 10, 2016·International Journal for Numerical Methods in Biomedical Engineering·Harsha T Garimella, Reuben H Kraft
Mar 17, 2018·PloS One·Harsha T GarimellaAndrzej J Przekwas
Jul 8, 2017·Journal of Neurotrauma·Calvin KuoEllen Kuhl
Nov 1, 2018·Annals of Biomedical Engineering·Wei Zhao, Songbai Ji
Sep 1, 2017·Biomechanics and Modeling in Mechanobiology·Calvin KuoDavid B Camarillo
May 14, 2017·Biomechanics and Modeling in Mechanobiology·Wei ZhaoSongbai Ji
Nov 25, 2019·Biomechanics and Modeling in Mechanobiology·Shaoju WuSongbai Ji
Sep 22, 2020·Brain Communications·Allen A ChampagneDouglas J Cook
May 11, 2017·Brain Informatics·William W LyttonTerence D Sanger
Jul 16, 2017·Annals of Biomedical Engineering·Wei ZhaoSongbai Ji
Jan 30, 2019·Annals of Biomedical Engineering·Amit Madhukar, Martin Ostoja-Starzewski
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May 26, 2018·Journal of Biomechanical Engineering·Calvin KuoDavid B Camarillo
Dec 2, 2020·Annals of Biomedical Engineering·Logan E MillerJoel D Stitzel
Jan 16, 2021·Journal of Neurotrauma·Zhou ZhouMichael Zeineh
Aug 30, 2021·Biomechanics and Modeling in Mechanobiology·A SinghM A Iqbal
Oct 8, 2021·Journal of Neurotrauma·Zhou ZhouMichael Zeineh

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Software Mentioned

pcBRA
DeclareMathSizes
MATLAB
ITK Segmentation and Registration Toolkit
ExploreDTI
Linux
SIMon
FreeSurfer

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Brain Injury & Trauma

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