White matter integrity and processing speed in sickle cell anemia

Neurology
Hanne StotesburyJamie M Kawadler

Abstract

The purpose of this retrospective cross-sectional study was to investigate whether changes in white matter integrity are related to slower processing speed in sickle cell anemia. Thirty-seven patients with silent cerebral infarction, 46 patients with normal MRI, and 32 sibling controls (age range 8-37 years) underwent cognitive assessment using the Wechsler scales and 3-tesla MRI. Tract-based spatial statistics analyses of diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) parameters were performed. Processing speed index (PSI) was lower in patients than controls by 9.34 points (95% confidence interval: 4.635-14.855, p = 0.0003). Full Scale IQ was lower by 4.14 scaled points (95% confidence interval: -1.066 to 9.551, p = 0.1), but this difference was abolished when PSI was included as a covariate (p = 0.18). There were no differences in cognition between patients with and without silent cerebral infarction, and both groups had lower PSI than controls (both p < 0.001). In patients, arterial oxygen content, socioeconomic status, age, and male sex were identified as predictors of PSI, and correlations were found between PSI and DTI scalars (fractional anisotropy r = 0.614, p < 0.00001; r ...Continue Reading

References

Sep 12, 2000·Archives of Pediatrics & Adolescent Medicine·C J BlaisdellG M Loughlin
Sep 20, 2001·The Journal of Pediatrics·W WangUNKNOWN Cooperative Study of Sickle Cell Disease
Mar 5, 2003·British Journal of Health Psychology·Kofi A. AnieDavid H. Bevan
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Mar 9, 2007·The American Journal of Clinical Nutrition·Laura E Murray-Kolb, John L Beard
Jul 28, 2007·The Behavioral and Brain Sciences·Rex E Jung, Richard J Haier
Mar 1, 2006·Journal of the American Statistical Association·Edsel A Peña, Elizabeth H Slate
May 13, 2010·JAMA : the Journal of the American Medical Association·Elliott P VichinskyUNKNOWN Neuropsychological Dysfunction and Neuroimaging Adult Sickle Cell Anemia Study Group
Jun 10, 2010·Psychological Assessment·Liza E San Miguel MontesCris Neblina
Feb 18, 2011·Journal of Pediatric Hematology/oncology·Nadia ScantleburyIsaac Odame
Oct 8, 2011·NeuroImage·Mark JenkinsonStephen M Smith
Nov 26, 2011·Journal of the International Neuropsychological Society : JINS·Matthew J HollocksMichelle de Haan
Dec 20, 2011·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·N RuffieuxR Sztajzel
Apr 25, 2012·AJR. American Journal of Roentgenology·Ali BalciErtugrul Egilmez
Oct 31, 2012·Neuropsychology Review·Ida Sue Baron, Peter John Anderson
Feb 14, 2014·Neurology·R Scott MackinUNKNOWN Neuropsychological Dysfunction and Neuroimaging Adult Sickle Cell Anemia Study Group
May 6, 2014·Imaging in Medicine·Wint Yan AungTammie Ls Benzinger
Jul 16, 2014·Pediatrics·Carol L RosenFenella J Kirkham
Aug 21, 2014·The New England Journal of Medicine·Michael R DeBaunJames F Casella
May 15, 2015·Stroke; a Journal of Cerebral Circulation·Jamie M KawadlerChris A Clark
Oct 7, 2015·PloS One·Nicolas ChevalierMonique K LeBourgeois
Jan 30, 2016·Brain : a Journal of Neurology·Lori C JordanManus J Donahue
Jun 7, 2016·American Journal of Hematology·Adam M BushJohn C Wood
Jul 10, 2016·Pediatric Blood & Cancer·Olubusola B OluwoleEnrico M Novelli
Dec 29, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jennifer M WatchmakerManus J Donahue

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Citations

Jul 18, 2019·Human Brain Mapping·Bhim M AdhikariPeter Kochunov
Mar 7, 2020·Stroke; a Journal of Cerebral Circulation·Mboka JacobChris A Clark
Sep 3, 2019·Frontiers in Neurology·Hanne StotesburyFenella J Kirkham
Sep 2, 2020·Annals of Neurology·Melanie E FieldsJin-Moo Lee
Jan 20, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Dermot MallonFrancesca Tona
Feb 23, 2021·Expert Review of Hematology·Hanne StotesburyFenella Jane Kirkham
Aug 20, 2020·Journal of Neuroscience Methods·Kouhei KamiyaShigeki Aoki
Apr 25, 2021·Lancet Neurology·Lori C JordanManus J Donahue
Jan 7, 2022·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hanne StotesburyFenella J Kirkham

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Software Mentioned

NODDI
neurovault
RStudio Desktop
FSL
NODDI MATLAB Toolbox
TractoR

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