White matter integrity in Asperger syndrome: a preliminary diffusion tensor magnetic resonance imaging study in adults.

Autism Research : Official Journal of the International Society for Autism Research
Oswald J N BloemenDeclan G M Murphy

Abstract

Autistic Spectrum Disorder (ASD), including Asperger syndrome and autism, is a highly genetic neurodevelopmental disorder. There is a consensus that ASD has a biological basis, and it has been proposed that it is a "connectivity" disorder. Diffusion Tensor Magnetic Resonance Imaging (DT-MRI) allows measurement of the microstructural integrity of white matter (a proxy measure of "connectivity"). However, nobody has investigated the microstructural integrity of whole brain white matter in people with Asperger syndrome. We measured the fractional anisotropy (FA), mean diffusivity (MD) and radial diffusivity (RD) of white matter, using DT-MRI, in 13 adults with Asperger syndrome and 13 controls. The groups did not differ significantly in overall intelligence and age. FA, MD and RD were assessed using whole brain voxel-based techniques. Adults with Asperger syndrome had a significantly lower FA than controls in 13 clusters. These were largely bilateral and included white matter in the internal capsule, frontal, temporal, parietal and occipital lobes, cingulum and corpus callosum. Adults with Asperger syndrome have widespread significant differences from controls in white matter microstructural integrity.

References

Jun 1, 1989·Journal of Autism and Developmental Disorders·C LordE Schopler
Aug 1, 1995·Archives of Neurology·B EgaasO Saitoh
Jan 1, 1995·Psychological Medicine·A BaileyM Rutter
Jan 1, 1994·Biophysical Journal·P J BasserD LeBihan
Feb 1, 1993·AJR. American Journal of Roentgenology·E CourchesneR Yeung-Courchesne
Apr 1, 1996·Journal of the American Academy of Child and Adolescent Psychiatry·J PivenN Andreasen
Dec 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C Pierpaoli, P J Basser
Aug 1, 1997·The American Journal of Psychiatry·J PivenS Arndt
Apr 21, 1998·Journal of Cardiac Failure·S OhtaniS Sasayama
Nov 20, 1998·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·K M Heilman, R L Gilmore
May 21, 1999·The European Journal of Neuroscience·S Baron-CohenS C Williams
Nov 26, 1999·The Journal of Neuropsychiatry and Clinical Neurosciences·F ManesS E Starkstein
Nov 27, 1999·Science·C D Frith, U Frith
Mar 29, 2000·Brain : a Journal of Neurology·R A Carper, E Courchesne
Jun 22, 2000·Trends in Cognitive Sciences·T AllisonG McCarthy
Nov 4, 2000·Neurology·A Y HardanM S Keshavan
Jan 5, 2002·Neuron·U Frith
May 8, 2002·Nature Reviews. Neuroscience·Matthew BrettAdrian M Owen
Jun 22, 2002·Brain : a Journal of Neurology·Grainne M McAlonanDeclan G M Murphy
Jul 24, 2002·Brain : a Journal of Neurology·Fulvia CastelliUta Frith
Aug 31, 2002·NeuroImage·Ruth A CarperEric Courchesne
Jun 21, 2003·Cerebral Cortex·Jennifer G LevittArthur W Toga
Jun 25, 2003·Brain : a Journal of Neurology·Marco CataniDominic H Ffytche
Sep 10, 2003·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Peter Mundy
Oct 17, 2003·Brain Research. Cognitive Brain Research·Matthew K Belmonte, Deborah A Yurgelun-Todd
Jan 28, 2004·Biological Psychiatry·Naama Barnea-GoralyAllan L Reiss
Mar 30, 2004·Annals of Neurology·Martha R HerbertVerne S Caviness
Aug 11, 2004·Trends in Cognitive Sciences·Georg Northoff, Felix Bermpohl
Aug 25, 2004·NeuroImage·Moo K ChungRichard J Davidson
Sep 24, 2004·Lancet Neurology·Chris Frith
Oct 21, 2004·Nature Neuroscience·Patrik VuilleumierRaymond J Dolan
Oct 29, 2004·Journal of Cognitive Neuroscience·Eric I Knudsen

❮ Previous
Next ❯

Citations

May 17, 2011·Journal of Autism and Developmental Disorders·Matteo PardiniLeonardo Emberti Gialloreti
Aug 9, 2012·Journal of Autism and Developmental Disorders·Karmen SchmidtCharles Henry
Dec 12, 2012·Journal of Autism and Developmental Disorders·Antonio NarzisiCosimo Urgesi
Jul 18, 2012·Molecular Psychiatry·C EckerD G M Murphy
Apr 20, 2011·Molecular Autism·Evdokia Anagnostou, Margot J Taylor
Nov 23, 2012·Molecular Autism·Michael V LombardoSimon Baron-Cohen
Sep 10, 2013·Journal of Autism and Developmental Disorders·Leonardo Emberti GialloretiPaolo Curatolo
May 16, 2014·Journal of Autism and Developmental Disorders·Miriam CooperDerek K Jones
Feb 26, 2016·Brain : a Journal of Neurology·Marco CataniDeclan G M Murphy
Mar 24, 2015·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Lauren E LiberoRajesh K Kana
Aug 21, 2012·Brain Research·Natalia M KleinhansStephen R Dager
Jul 23, 2011·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Frederick SundramDeclan G M Murphy
Dec 7, 2010·Brain Research·Kimberly A StiglerChristopher J McDougle
Oct 4, 2013·Autism Research : Official Journal of the International Society for Autism Research·Ulrika RoineMikko Sams
Jun 16, 2011·Human Brain Mapping·René C W MandlHilleke E Hulshoff Pol
Jul 13, 2012·Autism Research : Official Journal of the International Society for Autism Research·Brittany G TraversAndrew L Alexander
Sep 8, 2015·Journal of Psychiatric Research·Joana Bisol BalardinJoão Ricardo Sato
May 24, 2015·Journal of Autism and Developmental Disorders·Brittany G TraversJanet E Lainhart
Jul 6, 2015·Developmental Cognitive Neuroscience·Ingrid R OlsonGovinda Vyas
May 10, 2015·Neuroscience and Biobehavioral Reviews·Katharine ChisholmStephen J Wood
Jul 19, 2013·Cerebral Cortex·Boris C BernhardtTania Singer
Oct 1, 2014·Journal of Psychiatric Research·Kimito HiroseHidehiko Takahashi
Dec 1, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Stephanie H Ameis, Marco Catani
Jun 1, 2016·Frontiers in Human Neuroscience·Marwa M T IsmailAyman El-Baz
Aug 12, 2016·Human Brain Mapping·P Cédric M P KoolschijnHilde M Geurts
Aug 25, 2016·Brain Connectivity·Lauren E LiberoRajesh K Kana
Aug 5, 2017·Molecular Autism·Hendrik WesselingSabine Bahn
Jul 7, 2015·Harvard Review of Psychiatry·Pallavi RaneJean A Frazier
Sep 6, 2018·Social Cognitive and Affective Neuroscience·Bun YamagataYuta Aoki
Aug 24, 2017·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Lauren J RiceStewart L Einfeld
Dec 12, 2020·Brain Sciences·Alma Y Galvez-ContrerasOscar Gonzalez-Perez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asperger Syndrome

Asperger syndrome (AS), also known as Asperger's, is a developmental disorder characterized by significant difficulties in social interaction and nonverbal communication, along with restricted and repetitive patterns of behavior and interests. Discover the latest research on Asperger syndrome here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.