White matter integrity in small vessel disease is related to cognition

NeuroImage. Clinical
Anil M TuladharFrank-Erik de Leeuw

Abstract

Cerebral small vessel disease, including white matter hyperintensities (WMH) and lacunes of presumed vascular origin, is common in elderly people and is related to cognitive impairment and dementia. One possible mechanism could be the disruption of white matter tracts (both within WMH and normal-appearing white matter) that connect distributed brain regions involved in cognitive functions. Here, we investigated the relation between microstructural integrity of the white matter and cognitive functions in patients with small vessel disease. The Radboud University Nijmegen Diffusion tensor and Magnetic resonance Cohort study is a prospective cohort study among 444 independently living, non-demented elderly with cerebral small vessel disease, aged between 5500 and 85 years. All subjects underwent magnetic resonance imaging and diffusion tensor imaging scanning and an extensive neuropsychological assessment. We showed that loss of microstructural integrity of the white matter at specific locations was related to specific cognitive disturbances, which was mainly located in the normal-appearing white matter (p < 0.05, FWE-corrected for multiple comparisons). The microstructural integrity in the genu and splenium showed the highest sig...Continue Reading

References

Dec 1, 1996·Radiology·C PierpaoliG Di Chiro
Feb 9, 2000·Annals of Neurology·J C de GrootM M Breteler
Dec 18, 2001·Human Brain Mapping·Thomas E Nichols, Andrew P Holmes
Jan 5, 2002·Neuropsychology·S D Christman, R E Propper
Mar 28, 2003·The New England Journal of Medicine·Sarah E VermeerMonique M B Breteler
Jul 10, 2003·Lancet Neurology·Gustavo C RománHelena C Chui
Feb 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·M O'SullivanH S Markus
Jun 16, 2005·NeuroImage·John Ashburner, Karl J Friston
Aug 16, 2005·Biophysical Journal·Pabitra N Sen, Peter J Basser
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Nov 6, 2007·The New England Journal of Medicine·Meike W VernooijAad van der Lugt
Jan 29, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Arani NitkunanHugh S Markus
May 6, 2009·Archives of General Psychiatry·Meike W VernooijMonique M B Breteler
Aug 28, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·R TopakianH S Markus
Nov 17, 2009·Brain : a Journal of Neurology·Julio Acosta-CabroneroPeter J Nestor
May 19, 2010·Brain Pathology·Tomasz DziedzicWolfgang Brück
Dec 16, 2010·Brain : a Journal of Neurology·Karlijn F de LaatFrank-Erik de Leeuw
Jul 23, 2013·Lancet Neurology·Joanna M WardlawUNKNOWN STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1)

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Citations

Dec 22, 2015·Biochimica Et Biophysica Acta·Gargi BanerjeeDavid J Werring
Dec 26, 2015·Biochimica Et Biophysica Acta·Philip B GorelickDavid Nyenhuis
Jul 1, 2016·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Mario MascalchiStefano Diciotti
Mar 10, 2016·IEEE Journal of Biomedical and Health Informatics·Stefano CiulliStefano Diciotti
Dec 10, 2016·Human Brain Mapping·Anil M TuladharFrank-Erik de Leeuw
Oct 14, 2017·The Neuroradiology Journal·Maria M D'SouzaSubash Khushu
Feb 16, 2017·Stroke; a Journal of Cerebral Circulation·C Eleana ZhangRobert J van Oostenbrugge
Feb 6, 2017·Circulation Research·Martin Dichgans, Didier Leys
Apr 23, 2016·Stroke; a Journal of Cerebral Circulation·Marco PasiLeonardo Pantoni
Jan 4, 2019·Circulation Research·Joshua M TublinLoren E Wold
Oct 16, 2015·Human Brain Mapping·Anil M TuladharFrank-Erik de Leeuw
Sep 17, 2019·Annals of Clinical and Translational Neurology·Sofia FinsterwalderMarco Duering
Sep 13, 2019·Stroke; a Journal of Cerebral Circulation·Owen A WilliamsRebecca A Charlton
Feb 7, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Marco DueringMartin Dichgans
Jul 25, 2019·Stroke and Vascular Neurology·Jing Du, Qun Xu
Sep 15, 2020·Neurorehabilitation and Neural Repair·Maria VarkanitsaSwathi Kiran
Apr 30, 2016·AJNR. American Journal of Neuroradiology·W ReginoldA Garcia
May 11, 2018·Brain Imaging and Behavior·Mario MascalchiUNKNOWN VMCI-Tuscany study group
May 29, 2018·Nature Reviews. Neurology·Annemieke Ter TelgteFrank-Erik de Leeuw
Aug 27, 2018·Brain Imaging and Behavior·Morag E TaylorJacqueline C T Close
May 13, 2018·Stroke; a Journal of Cerebral Circulation·Loes C A Rutten-JacobsMatthew Traylor
Dec 24, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yucheng GuYun Xu
Jul 19, 2019·Frontiers in Aging Neuroscience·Michelle R CauncaClinton B Wright
Sep 29, 2019·Journal of Alzheimer's Disease : JAD·Glykeria TsentidouMagda Tsolaki

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Software Mentioned

TBSS
PATCH
Functional MRI of the Brain Software Library ( FSL )
Functional MRI of the Brain diffusion toolbox
SPM
DTIFit

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