White matter integrity in the fronto-striatal accumbofrontal tract predicts impulsivity

Brain Imaging and Behavior
Toshikazu IkutaKatherine H Karlsgodt

Abstract

Frontostriatal projections have been shown to mediate impulsivity. Recent findings have demonstrated that the projection from the prefrontal cortex to the nucleus accumbens (the accumbofrontal tract) can be isolated by using probabilistic tractography on human brain MRI data, specifically, diffusion tensor images (DTI). Using DTI tractography, we isolated the tract and tested its association with the impulsivity. DTI data from 143 individuals obtained from Nathan Kline Institute-Rockland Sample was used along with the impulsivity measure assessed by the UPPS (urgency, premeditation, perseverance, and sensation seeking) impulsive behavior total score. Probabilistic tractography was first performed between the prefrontal cortex and nucleus accumbens, then, as a measure of white matter integrity in the tract, fractional anisotropy was calculated for each individual's tract. In the multiple regression, accumbofrontal FA showed significant positive association with the impulsivity, suggesting that the accumbofrontal tract integrity may contribute to individual differences in impulsivity. This study bridges the literature in rodents, in which this glutamatergic projection has been shown to mediate impulsive behavior, and the findings...Continue Reading

References

Jan 1, 1994·Biophysical Journal·P J BasserD LeBihan
Nov 13, 2004·Neuroreport·Matthew J HoptmanKelvin O Lim
Mar 1, 2006·Clinical Psychology Review·Catharine A WinstanleyTrevor W Robbins
Jun 30, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew L AlexanderAaron S Field
May 30, 2008·Pharmacology, Biochemistry, and Behavior·Alberto Del Arco, Francisco Mora
Jun 7, 2008·Science·David BelinBarry J Everitt
Jan 6, 2009·Biological Psychiatry·James M BjorkDaniel W Hommer
Jan 19, 2011·Neurosurgery·Philippe RigoardBenoit Bataille
Apr 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adam C MarTrevor W Robbins
Apr 13, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gregory R Samanez-LarkinBrian Knutson
Apr 20, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew R RoeschGeoffrey Schoenbaum
Aug 1, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wouter van den BosSamuel M McClure
Jan 8, 2015·Psychopharmacology·Lindsay M SquegliaSusan F Tapert
Jul 21, 2015·Frontiers in Human Neuroscience·Melanie TscherneggMartin Kronbichler
Feb 13, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michelle AchterbergEveline A Crone
Jul 11, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Masafumi SanefujiMichel Thiebaut de Schotten
Feb 18, 2017·Nature Reviews. Neuroscience·Jeffrey W Dalley, Trevor W Robbins

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Citations

Mar 5, 2020·Brain Imaging and Behavior·Vincenzo AlfanoCarlo Cavaliere
Feb 5, 2021·Brain Structure & Function·Haeme R P ParkRuth M Krebs
May 4, 2021·Frontiers in Psychology·Kristof KeidelUlrich Ettinger
Sep 26, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bryan V KennedySeth D Pollak

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Software Mentioned

FSL Linear Registration Tool
R
fcon
FSL
Probtrackx
Diffusion Toolbox
Bedpostx
FSL Brain Extraction Tool

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