White matter integrity in young smokers: a tract-based spatial statistics study

Addiction Biology
Dahua YuJie Tian

Abstract

Previous diffusion tensor imaging (DTI) studies revealed contradictory effects of smoking on fractional anisotropy (FA). Multiple DTI-derived indices may help to deduce the pathophysiological type of white matter (WM) changes and provide more specific biomarkers of WM neuropathology in the whole brain of young smokers. Twenty-three young smokers and 22 age-, education- and gender-matched healthy non-smoking controls participated in this study. Tract-based spatial statistics was employed to investigate the WM microstructure in young smokers by integrating multiple indices, including FA, mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD). Compared with healthy non-smoking controls, young smokers showed significantly increased FA with increased AD and decreased RD in several brain regions, while no difference in MD was observed. Specifically, the overlapped WM regions with increased FA, increased AD and decreased RD were found in the right posterior limb of the internal capsule, the right external capsule and the right superior corona radiata. Additionally, average FA and RD values in the WM regions mentioned earlier were significantly correlated with pack-years and Fagerström Test for Nicotine Dependence, w...Continue Reading

References

Sep 1, 1991·British Journal of Addiction·T F HeathertonK O Fagerström
Jan 7, 2004·Biological Psychiatry·Arthur L BrodyEdythe D London
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Sep 29, 2006·The European Journal of Neuroscience·Jürgen GallinatMario Staedtgen
Jun 30, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew L AlexanderAaron S Field
Dec 7, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Leslie K JacobsenW Einar Mencl
Jan 12, 2008·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Robert H PaulEvian Gordon
Oct 7, 2008·NeuroImage·Catherine J Stoodley, Jeremy D Schmahmann
Apr 25, 2009·Alcoholism, Clinical and Experimental Research·Tim McQueenySusan F Tapert
Aug 12, 2009·Brain and Language·Catherine J Stoodley, Jeremy D Schmahmann
Aug 21, 2009·Nature Reviews. Cancer·Prabhat Jha
Jan 27, 2010·Psychopharmacology·Marc C TobiasEdythe D London
Jul 28, 2010·PloS One·Scott D LaneFrederick Gerard Moeller
Aug 12, 2010·NeuroImage·Xiaochu ZhangElliot A Stein
Sep 30, 2010·Biological Psychiatry·Simone KühnJürgen Gallinat
Jan 12, 2011·Annual Review of Clinical Psychology·Moriah E Thomason, Paul M Thompson
Mar 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Nora D VolkowFrank Telang
Jun 28, 2011·Brain : a Journal of Neurology·Rob A R GonsFrank-Erik de Leeuw
Oct 21, 2011·Nature Reviews. Neuroscience·Rita Z Goldstein, Nora D Volkow
Jan 5, 2012·Psychopharmacology·Matthew HudkinsEdythe D London
May 9, 2012·Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors·Joanna JacobusSusan F Tapert
Nov 15, 2012·Cephalalgia : an International Journal of Headache·Dahua YuJie Tian
Jul 13, 2013·Neuroscience and Biobehavioral Reviews·Simon T E BakerDan I Lubman
Jan 3, 2014·The New England Journal of Medicine·Prabhat Jha, Richard Peto
Mar 4, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Angelica M MoralesEdythe D London

❮ Previous
Next ❯

Citations

May 23, 2015·Addiction Biology·Rick E Bernardi
Jun 28, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Dahua YuXiaoqi Lu
Apr 23, 2019·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Megan M KangiserKrista M Lisdahl
Sep 16, 2017·Frontiers in Human Neuroscience·Peiyu HuangMinming Zhang
Jul 21, 2016·Brain Imaging and Behavior·Yangding LiJie Tian
Mar 16, 2017·Brain Imaging and Behavior·Yajuan ZhangKai Yuan
Aug 6, 2020·Frontiers in Psychiatry·Ting XueKai Yuan
Aug 28, 2020·Frontiers in Human Neuroscience·Shahnaza HamidullahJibran Y Khokhar
Aug 23, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kai YuanJie Tian

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.