White Matter Integrity of Specific Dentato-Thalamo-Cortical Pathways is Associated with Learning Gains in Precise Movement Timing

Cerebral Cortex
Robert SchulzFriedhelm C Hummel

Abstract

The dentato-thalamo-cortical tract (DTCT) connects the lateral cerebellum with contralateral motor and nonmotor areas, such as the primary motor cortex (M1), the ventral premotor cortex (PMv), and the dorsolateral prefrontal cortex (DLPFC). As the acquisition of precisely timed finger movements requires the interplay between these brain regions, the structural integrity of the underlying connections might explain variance in behavior. Diffusion tensor imaging was used to 1) reconstruct the DTCT connecting the dentate nucleus with M1, PMv, and DLPFC and 2) examine to which extent their microstructural integrity (tract-related fractional anisotropy) relates to learning gains in a motor-sequence learning paradigm consisting of a synchronization and continuation part. Continuous DTCT were reconstructed from the dentate nucleus to all cortical target areas. We found that the microstructural integrity of the DTCT connecting the left dentate nucleus with the right DLPFC was associated with better early consolidation in rhythm continuation (R = -0.69, P = 0.02). The present data further advances the knowledge about a right-hemispheric timing network in the human brain with the DLPFC as an important node contributing to learning gains i...Continue Reading

References

Dec 15, 1995·Annals of the New York Academy of Sciences·P NichelliJ Grafman
Aug 29, 1996·Nature·S GeyerP E Roland
Mar 1, 1997·Journal of Neurophysiology·M JueptnerR E Passingham
Aug 26, 1998·Brain Research. Cognitive Brain Research·J A MangelsN Shimizu
Dec 1, 1998·Journal of Cognitive Neuroscience·V B PenhuneA C Evans
Mar 12, 1999·Science·E E Smith, J Jonides
Mar 17, 2000·Brain Research. Brain Research Reviews·F A Middleton, P L Strick
Feb 27, 2001·Nature Neuroscience·S M RaoD L Harrington
Oct 12, 2001·Journal of Cognitive Neuroscience·N Ramnani, R E Passingham
Jan 22, 2002·Nature Neuroscience·Christos ConstantinidisPatricia S Goldman-Rakic
May 17, 2002·Current Opinion in Neurobiology·Okihide HikosakaHiroyuki Nakahara
Oct 5, 2002·Journal of Neurophysiology·Katsuyuki SakaiRichard E Passingham
Dec 17, 2002·NeuroImage·A DimitrovaD Timmann
Jan 11, 2003·Journal of Neurophysiology·Richard P Dum, Peter L Strick
Feb 13, 2003·Annals of the New York Academy of Sciences·Richard B IvryJörn Diedrichsen
May 15, 2003·Current Opinion in Neurobiology·Penelope A Lewis, R Christopher Miall
Dec 19, 2003·Annals of the New York Academy of Sciences·Michael H Thaut
Dec 20, 2003·NeuroImage·Satoru Hayasaka, Thomas E Nichols
Mar 26, 2004·Cognitive, Affective & Behavioral Neuroscience·Tor D Wager, Edward E Smith
Feb 18, 2005·Journal of Neurophysiology·A Floyer-Lea, P M Matthews
Aug 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Stéphane LehéricyJulien Doyon
Jan 26, 2006·Behavioural Processes·P A Lewis, R C Miall
May 5, 2006·Journal of Neurophysiology·Timothy VerstynenRichard B Ivry
Aug 11, 2006·Trends in Cognitive Sciences·Penelope A Lewis, R Chris Miall
Mar 27, 2007·Trends in Cognitive Sciences·Ricarda I Schubotz
Apr 27, 2007·Journal of Neurophysiology·Miguel Fernandez Del OlmoJohn C Rothwell
Sep 21, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Valentina TomassiniHeidi Johansen-Berg
Feb 29, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jill X O'ReillyAnna Christina Nobre
Apr 5, 2008·Cerebral Cortex·Joyce L ChenRobert J Zatorre
Apr 18, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fredrik UllénGuy Madison

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Citations

Jan 22, 2015·Cerebral Cortex·Maximilian J WesselFriedhelm C Hummel
Apr 9, 2015·Frontiers in Computational Neuroscience·Ahmed A Moustafa
Apr 20, 2017·Frontiers in Neurology·Sheng Li
Mar 17, 2020·Journal of Neurological Surgery. Part A, Central European Neurosurgery·Tim WendeJürgen Meixensberger
Jul 23, 2016·Brain Imaging and Behavior·Luis EudaveMaría A Pastor
Oct 14, 2014·Frontiers in Systems Neuroscience·Krystal L ParkerNancy C Andreasen
Jan 21, 2021·Scientific Reports·Maximilian J WesselFriedhelm C Hummel

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