White matter integrity, substance use, and risk taking in adolescence.

Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors
Joanna JacobusSusan F Tapert

Abstract

White matter development is important for efficient communication between brain regions, higher order cognitive functioning, and complex behaviors. Adolescents have a higher propensity for engaging in risky behaviors, yet few studies have explored associations between white matter integrity and risk taking directly. Altered white matter integrity in mid-adolescence was hypothesized to predict subsequent risk taking behaviors 1.5 years later. Adolescent substance users (predominantly alcohol and marijuana, n = 47) and demographically similar nonusers (n = 49) received diffusion tensor imaging at baseline (ages 16-19), and risk taking measures at both baseline and an 18-month follow-up (i.e., at ages 17-20). Brain regions of interest were the fornix, superior corona radiata, superior longitudinal fasciculus, and superior fronto-occipital fasciculus. In substance-using youth (n = 47), lower white matter integrity at baseline in the fornix and superior corona radiata predicted follow-up substance use (ΔR2 = 10-12%, ps < .01), and baseline fornix integrity predicted follow-up delinquent behaviors (ΔR2 = 10%, p < .01) 1.5 years later. Poorer fronto-limbic white matter integrity was linked to a greater propensity for future risk takin...Continue Reading

Citations

Oct 24, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Alessio Maria MonteleoneMario Maj
Aug 6, 2013·Brain Sciences·Joanna JacobusSusan F Tapert
Sep 12, 2019·Frontiers in Psychiatry·Michaela Hiebler-Ragger, Human-Friedrich Unterrainer
Jan 8, 2015·Psychopharmacology·Lindsay M SquegliaSusan F Tapert
Sep 17, 2016·Social Neuroscience·George ZacharopoulosDavid E J Linden
Feb 20, 2016·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Eveline A CroneJiska S Peper
Mar 18, 2016·Current Psychiatry Reports·Lindsay M Squeglia, Kevin M Gray
Aug 27, 2014·Alcoholism, Clinical and Experimental Research·Lindsay M SquegliaDouglas B Matthews
May 16, 2017·Frontiers in Human Neuroscience·Human-Friedrich UnterrainerAndreas Fink
Jul 12, 2017·Addiction Biology·Margaret A BroadwaterYen-Yu Ian Shih
Dec 19, 2012·Annual Review of Clinical Psychology·Joanna Jacobus, Susan F Tapert
Oct 27, 2020·The International Journal of Neuropsychopharmacology·Alysha A SultanBenjamin I Goldstein
May 27, 2020·Developmental Cognitive Neuroscience·Tiffany C HoIan H Gotlib

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