White matter intercompartmental water exchange rates determined from detailed modeling of the myelin sheath

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Peter van Gelderen, Jeff H Duyn

Abstract

Magnetization exchange (ME) between hydrogen protons of water and large molecules (semisolids [SS]) in lipid bilayers is an important factor in MRI signal generation and can be exploited to study white matter pathology. Current models used to quantify ME in white matter generally consider water to reside in 1 or 2 distinct compartments, ignoring the complexities of the myelin sheath's multicompartment structure of alternating myelin SS and myelin water (MW) layers. Here, we investigated the effect of this by fitting ME data obtained from human brain at 7 T with a multilayer model of myelin. A multi-echo acquisition for a T2* -based separation of MW from other water signals was combined with various preparation pulses to change the (relative) state of the SS and water pools and analyzed by fitting with a multilayer exchange model. The estimated lifetime within a single MW layer was 260 µs, corresponding to a lipid bilayer permeability of 6.7 µm/s. The magnetization lifetime of the aggregate of all MW was estimated at 13 ms, shorter than previously reported values in the range of 40 to 140 ms. Contrary to expectations and previous reports, ME between protons in myelin SS and water is not limited by the myelin sheath but rather by...Continue Reading

References

Aug 17, 1978·Biochimica Et Biophysica Acta·T Conlon, R Outhred
Aug 1, 1976·The Journal of General Physiology·A Finkelstein
Dec 11, 1992·Brain Research·F AboitizE Zaidel
Nov 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R J OrdidgeP Mansfield
Jun 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S H KoenigN Lundbom
Jul 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·C R Worthington
Jul 1, 1967·The Journal of General Physiology·A Cass, A Finkelstein
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R A LaursenM B Lees
Feb 25, 1982·Journal of Molecular Biology·N P FranksD L Caspar
Aug 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D F GochbergJ C Gore
May 23, 1998·NMR in Biomedicine·A Tannús, M Garwood
Nov 26, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G J StaniszR M Henkelman
Oct 25, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J G Sled, G B Pike
Jan 31, 2002·Journal of the American Chemical Society·Daniel HusterMei Hong
Mar 31, 1965·Annals of the New York Academy of Sciences·F A VANDENHEUVEL
Oct 4, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T A BjarnasonA L MacKay
Apr 8, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Adrienne N DulaMark D Does
Jul 29, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ives R LevesqueG Bruce Pike
Mar 8, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Saeed KalantariAlex L MacKay
Jun 30, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kevin D HarkinsMark D Does
Sep 4, 2012·NeuroImage·Richard D DortchSeth A Smith
Oct 24, 2012·Proceedings of the National Academy of Sciences of the United States of America·Samuel Wharton, Richard Bowtell
Dec 13, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Richard D DortchMark D Does
Mar 27, 2013·NeuroImage·Pascal SatiJeff H Duyn
Apr 30, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kevin D HarkinsMark D Does
Aug 22, 2015·Journal of Magnetic Resonance·R BartaC A Michal
Jan 3, 2016·NeuroImage·Peter van GelderenJeff H Duyn
Jun 9, 2016·Physics in Medicine and Biology·K D Harkins, M D Does
Jun 28, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter van GelderenJeff H Duyn
Feb 6, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xu JiangJeff H Duyn
Jun 1, 1972·Annals of the New York Academy of Sciences·D A Kirschner, D L D Caspar

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Citations

Apr 11, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Felix SchybollHeiko Neeb
Jul 28, 2019·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Hanwen LiuCornelia Laule
Feb 13, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Elena KlebanRichard Bowtell
Jan 17, 2021·Journal of Magnetic Resonance·Alan P ManningCarl A Michal
Mar 8, 2020·NeuroImage·Yicun WangJeff H Duyn
May 9, 2021·NeuroImage·Renaud HédouinJosé P Marques
Nov 19, 2019·Neurobiology of Aging·Mustapha BouhraraRichard G Spencer

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