White matter microstructural alterations in clinically isolated syndrome and multiple sclerosis

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Jing HuangKuncheng Li

Abstract

This study aims to determine whether and how diffusion alteration occurs in the earliest stage of multiple sclerosis (MS) and the differences in diffusion metrics between CIS and MS by using the tract-based spatial statistics (TBSS) method based on diffusion tensor imaging (DTI). Thirty-six CIS patients (mean age ± SD: 34.0 years ± 12.6), 36 relapsing-remitting multiple sclerosis (RRMS) patients (mean age ± SD: 35.0 years ± 9.4) and 36 age- and gender-matched normal controls (NCs) were included in this study. Voxel-wise analyses were performed with TBSS using multiple diffusion metrics, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (λ1) and radial diffusivity (λ23). In the CIS patients, TBSS analyses revealed diffusion alterations in a few white matter (WM) regions including the anterior thalamic radiation, corticospinal tract, inferior fronto-occipital fasciculus, superior longitudinal fasciculus, body and splenium of the corpus callosum, internal capsule, external capsule, and cerebral peduncle. MS patients showed more widespread diffusion changes (decreased FA, increased λ1, λ23 and MD) than CIS. Exploratory analyses also revealed the possible associations between WM diffusion metrics and cli...Continue Reading

Citations

May 25, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Bálint KincsesZsigmond Tamás Kincses
Dec 22, 2020·Frontiers in Human Neuroscience·Jing HuangJie Lu
Apr 28, 2021·Brain : a Journal of Neurology·Sara ColloroneAhmed T Toosy
May 26, 2020·Seminars in Ultrasound, CT, and MR·Minjeong Kim, Valerie Jewells

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