White matter microstructural alterations in amblyopic adults revealed by diffusion spectrum imaging with systematic tract-based automatic analysis

The British Journal of Ophthalmology
Tzu-Hsun TsaiWen-Yih Isaac Tseng

Abstract

We investigated the microstructural changes in white matter of adults with amblyopia using diffusion spectrum imaging with systematic tract-based automatic analysis of the whole brain. Ten adults with amblyopia (six women and four men, 33.6±10.6 years old on average) and 20 age- and sex-matched normal-sighted controls were enrolled. The mean generalised fractional anisotropy (GFA) was measured in 76 white matter tracts and compared between the experimental and control groups using a threshold-free cluster-weighted method and t-test. A 2-percentile cut-off was used to identify segments with the greatest differences between the two groups. Participants with amblyopia had significantly lower GFA values than the controls in 11 segments located in nine white matter tracts, which included the following: left arcuate fasciculus, left frontal aslant tract, left fornix and left inferior fronto-occipital fasciculus of the association fibres; left thalamic radiations of the auditory nerve and bilateral optic radiations of the projection fibres; and genu and middle temporal gyrus of the callosal fibres. Amblyopic participants had statistically higher GFA values in the bilateral uncinate fasciculus than those of the controls. This prelimina...Continue Reading

References

Jan 27, 1998·Ophthalmology·K AtteboR Sparkes
Apr 19, 2000·Journal of Cognitive Neuroscience·R Cabeza, L Nyberg
Apr 23, 2005·Human Brain Mapping·Janine D MendolaKenneth K Kwong
Oct 26, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Van J WedeenRobert M Weisskoff
Feb 1, 2008·Investigative Ophthalmology & Visual Science·Ann L WebberBrian Brown
Nov 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Dorothee SaurCornelius Weiller
Mar 18, 2009·The European Journal of Neuroscience·Robert F HessKathy T Mullen
Jan 8, 2011·Investigative Ophthalmology & Visual Science·Catherine M SuttleSimon Grant
Jan 15, 2011·NeuroImage·Fang-Cheng YehWen-Yih Isaac Tseng
Oct 6, 2012·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Agnes M F Wong
Mar 7, 2015·Investigative Ophthalmology & Visual Science·Cindy NarinesinghAgnes M F Wong
Aug 5, 2015·Investigative Ophthalmology & Visual Science·Yiran DuanAviv Mezer
Feb 21, 2016·Behavioural Brain Research·Ewa Niechwiej-SzwedoW Richard Staines

❮ Previous
Next ❯

Citations

Mar 19, 2021·Frontiers in Neurology·Emanuele La CorteGraziano Serrao

❮ Previous
Next ❯

Software Mentioned

TBAA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.