White matter microstructural changes are related to cognitive dysfunction in essential tremor

Scientific Reports
Julián Benito-LeónJuan Pablo Romero

Abstract

Diffusion tensor imaging (DTI) studies have detected white matter microstructural changes in essential tremor (ET). However, it is still unclear whether these changes are related to cognitive deficits, which have been described in ET patients. DTI-derived fractional anisotropy, mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity measures were compared between 23 ET patients and 23 age-, gender-, and education-matched healthy individuals, using whole-brain tract-based spatial statistics. Correlations of white matter changes with scores obtained from a detailed neuropsychological assessment were subsequently examined. ET patients demonstrated increases in MD in the bilateral posterior corona radiata, bilateral superior longitudinal fasciculus, bilateral fornix (cres)/stria terminalis, genu and splenium of the corpus callosum, bilateral anterior and posterior limbs of internal capsule, bilateral retrolenticular region part of internal capsule, and left posterior thalamic radiation. Except for the genu of the corpus callosum, an increase in AD values was also found in these same tracts. Furthermore, increased MD and AD values in different white matter areas was negatively correlated with performance on language an...Continue Reading

References

Aug 1, 1987·AJR. American Journal of Roentgenology·F FazekasR A Zimmerman
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Jan 13, 2006·Neurology·Julián Benito-LeónUNKNOWN Neurological Disorders in Central Spain (NEDICES) Study Group
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
May 24, 2006·Neurology·Julián Benito-LeónUNKNOWN Neurological Disorders in Central Spain Study Group
Nov 23, 2006·Nature Clinical Practice. Neurology·Julián Benito-León, Elan D Louis
Apr 10, 2007·Lancet·Julián Benito-León, Elan D Louis
May 23, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Félix Bermejo-ParejaUNKNOWN Neurological Disorders in Central Spain (NEDICES) Study Group
Aug 22, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E D LouisUNKNOWN Neurological Disorders in Central Spain (NEDICES) Study Group
Oct 9, 2007·AJNR. American Journal of Neuroradiology·D H ShinP H Lee
Dec 13, 2007·Neuroepidemiology·Julián Benito-LeónUNKNOWN Neurological Disorders in Central Spain (NEDICES) Study Group
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Dec 9, 2008·NeuroImage·Mark W WoolrichStephen M Smith
Jan 27, 2009·Neuroepidemiology·Julián Benito-León
Feb 21, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ming-Chang ChiangPaul M Thompson
Sep 1, 2009·Journal of the Neurological Sciences·Julián Benito-LeónElan D Louis
Nov 17, 2009·Brain : a Journal of Neurology·Julio Acosta-CabroneroPeter J Nestor
Jun 16, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Elan D LouisUNKNOWN Neurological Disorders in Central Spain (NEDICES) Study Group
Jun 22, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E D LouisUNKNOWN Neurological Disorders in Central Spain (NEDICES) Study Group
Jun 24, 2010·Human Brain Mapping·Johannes C KleinRüdiger Hilker
Feb 10, 2011·Journal of Alzheimer's Disease : JAD·Julián Benito-LeónFélix Bermejo-Pareja
Mar 31, 2011·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Bhavani Shankara BagepallyPramod Kumar Pal
Jul 13, 2011·Brain : a Journal of Neurology·Luca PassamontiAldo Quattrone
Aug 16, 2011·Brain : a Journal of Neurology·David J SharpRobert Leech
Feb 3, 2012·Parkinsonism & Related Disorders·Jitender SainiPramod Kumar Pal
May 24, 2013·Neurology·Julián Benito-LeónFélix Bermejo-Pareja
Jul 13, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Julián Benito-LeónFélix Bermejo-Pareja
Jul 16, 2013·Trends in Cognitive Sciences·Elissa M AminoffMoshe Bar
Aug 7, 2013·World Neurosurgery·Alexander LernerMeng Law
Feb 1, 2014·Neurobiology of Disease·Govinda R PoudelGary F Egan
Feb 18, 2014·NeuroImage·Anderson M WinklerThomas E Nichols
Mar 13, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K S BhalsingP K Pal
May 13, 2014·Brain Structure & Function·Yuko KoshimoriAntonio P Strafella
Aug 15, 2014·Tremor and Other Hyperkinetic Movements·Julián Benito-León
Oct 24, 2014·AJNR. American Journal of Neuroradiology·K S BhalsingP K Pal
Jun 6, 2015·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Elan D Louis
Sep 27, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Weidong FangTianyou Luo
Nov 2, 2015·The Cerebellum·Julián Benito-León, Andrés Labiano-Fontcuberta
Dec 15, 2015·Medicine·Julián Benito-LeónEduardo Rocon

❮ Previous
Next ❯

Citations

Feb 5, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·V Mato-AbadJ Benito-León
May 30, 2019·European Radiology·Sara PietracupaPatrizia Pantano
Sep 11, 2020·European Journal of Cancer Care·Noorazrul Yahya, Hanani A Manan
Mar 20, 2019·Journal of Neural Transmission·Shweta PrasadPramod Kumar Pal
May 13, 2018·Brain Sciences·Gabriele MandarelliStefano Ferracuti
Jan 27, 2020·Journal of Neural Transmission·Shweta PrasadPramod Kumar Pal

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

FSL
FSLview
Statistical Package for the Social Sciences ( SPSS )
FMRIB Toolbox
FMRIB Software Library ( FSL )
FMRIB Brain Extraction Toolbox BET
TBSS
FSL Randomize Tool
FMRIB58

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.