White matter microstructure alterations in primary dysmenorrhea assessed by diffusion tensor imaging

Scientific Reports
Peng LiuVince D Calhoun


Primary dysmenorrhea (PDM), a significant public health problem for adolescents and young women, is characterized by painful menstrual cramps. Recent neuroimaging studies have revealed that brain functional and structural abnormalities are related to the pathomechanism of PDM. However, it is not clear whether there are white matter (WM) alterations in PDM. We analyzed diffusion tensor imaging data from 35 patients and 35 healthy controls (HCs) matched for age and handedness. Tract-based spatial statistics and probabilistic tractography were used to measure integrity of WM microstructure. Compared to HCs, patients had increased fractional anisotropy (FA) along with decreased mean diffusivity (MD) and radial diffusivity (RD) in the corpus callosum (CC), superior longitudinal fasciculus (LF), corona radiata (CR), internal capsule (IC) and external capsule (EC). The FA of the splenium CC and right IC positively correlated with PDM duration while FA of the right anterior CR positively correlated with PDM severity in patient group. These WM tracts were found to show connections to other brain regions implicated in sensoimotor, affective, cognitive and pain processing functions through tractography. These findings provide preliminary ...Continue Reading


May 11, 2018·Journal of Psychosomatic Obstetrics and Gynaecology·Zahra BajalanZainab Alimoradi


Sep 1, 1978·Journal of Behavioral Medicine·D J Cox, R G Meyer
Jan 1, 1986·Annual Review of Neuroscience·G E AlexanderP L Strick
Aug 1, 1987·Pain·R Melzack
Dec 1, 1965·Archives of General Psychiatry·W W ZungM J Short
Dec 1, 1974·Journal of Neurosurgery·J E AdamsH L Fields
Nov 1, 1971·Psychosomatics·W W Zung
Jan 1, 1994·Archives of Oral Biology·P A McGrath
Aug 15, 1997·Science·P RainvilleM Catherine Bushnell
Nov 18, 2000·Journal of Neurology·K NakanoH Ushiro
Mar 29, 2001·Journal of Magnetic Resonance Imaging : JMRI·D Le BihanH Chabriat
Nov 15, 2001·Journal of Occupational Rehabilitation·S J Linton
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Nov 15, 2002·Paediatric Drugs·Zeev Harel
Dec 19, 2002·NMR in Biomedicine·Peter J Basser, Derek K Jones
Feb 22, 2003·European Journal of Radiology·Roland Bammer
Jun 17, 2003·Nature Neuroscience·Timothy E J BehrensPaul M Matthews
Dec 3, 2003·Radiology·Setsu WakanaSusumu Mori
May 25, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Volker NeugebauerJeong S Han
Jul 3, 2004·Journal of Computer Assisted Tomography·Osamu AbeKuni Ohtomo
Sep 16, 2004·The Journal of Comparative Neurology·Jeremy D SchmahmannDeepak N Pandya
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Jun 28, 2005·European Journal of Pain : EJP·A Vania ApkarianJon-Kar Zubieta
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Aug 21, 2008·Obstetrical & Gynecological Survey·Brittany BettendorfFrank Tu
Feb 25, 2009·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Lorah D DornElizabeth J Susman
Apr 14, 2009·NeuroImage·Cheng-Hao TuJen-Chuen Hsieh
Apr 30, 2009·Annual Review of Neuroscience·Sarina M RodriguesRobert M Sapolsky
Oct 13, 2009·Nature Neuroscience·Jan ScholzHeidi Johansen-Berg
Aug 14, 2010·Pain·Cheng-Hao TuJen-Chuen Hsieh
Oct 27, 2010·Neuropsychologia·Edith V SullivanAdolf Pfefferbaum
Feb 1, 2011·Methods in Molecular Biology·Derek K Jones, Alexander Leemans
Mar 1, 2011·Journal of Minimally Invasive Gynecology·Jennifer Droz, Fred M Howard
Apr 7, 2011·Brain Research·Jerry Yeou-Wei ChenKaren D Davis

Related Concepts

Primary Dysmenorrhea
Fanconi Anemia
Lymphoma, Non-Hodgkin
Functional Neuroimaging
Entire Internal Capsule of Brain
Right Anterior
Superior Sagittal Sinus

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