White matter microstructure correlates of general and specific second-order factors of psychopathology

NeuroImage. Clinical
Kendra E HintonDavid H Zald

Abstract

Increasing data indicate that prevalent forms of psychopathology can be organized into second-order dimensions based on their correlations, including a general factor of psychopathology that explains the common variance among all disorders and specific second-order externalizing and internalizing factors. Nevertheless, most existing studies on the neural correlates of psychopathology employ case-control designs that treat diagnoses as independent categories, ignoring the highly correlated nature of psychopathology. Thus, for instance, although perturbations in white matter microstructure have been identified across a range of mental disorders, nearly all such studies used case-control designs, leaving it unclear whether observed relations reflect disorder-specific characteristics or transdiagnostic associations. Using a representative sample of 410 young adult twins oversampled for psychopathology risk, we tested the hypothesis that some previously observed relations between white matter microstructure properties in major tracts and specific disorders are related to second-order factors of psychopathology. We examined fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). White matter correlates of all...Continue Reading

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Citations

Aug 19, 2020·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Sarah FurlongMargaret A Sheridan
Jan 13, 2021·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Benjamin B LaheyDavid H Zald
Feb 12, 2021·Current Opinion in Psychology·Peter Fonagy, Chloe Campbell
Feb 3, 2021·Molecular Psychiatry·Emma SprootenCorina U Greven

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Software Mentioned

FreeSurfer
fMRIB
FSL
RESTORE
CAMINO
TICV
Brain Extraction Tool ( BET )
Mplus
Functional Magnetic Resonance Imaging of the Brain Software Li...
Linear Image Registration Tool ( FLIRT )

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