DOI: 10.1101/459396Nov 1, 2018Paper

White Matter Microstructure Correlates of General and Specific Second-Order Factors of Psychopathology

BioRxiv : the Preprint Server for Biology
Kendra E HintonDavid H Zald


Increasing data indicate that prevalent forms of psychopathology can be organized into second- order dimensions based on their correlations, including a general factor of psychopathology that explains the common variance among all disorders and specific second-order externalizing and internalizing factors. Despite this organization, and high levels of comorbidity between diagnoses, most existing studies on the neural correlates of psychopathology employ case-control designs that treat diagnoses as independent categories. Thus, for instance, although perturbations in white matter microstructure have been identified across a range of disorders, the majority of such studies have used case-control designs, leaving it unclear whether observed relations reflect disorder specific characteristics, or transdiagnostic patterns. Using a representative community twin sample of 410 young adults, we tested the hypothesis that some relations between white matter microstructure properties in major tracts are related to second- order factors of psychopathology. We examined fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). White matter correlates of all second-order factors were identified after controlling for mul...Continue Reading

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