Nov 1, 2018

White Matter Microstructure Correlates of General and Specific Second-Order Factors of Psychopathology

BioRxiv : the Preprint Server for Biology
Kendra E HintonDavid H. Zald

Abstract

Increasing data indicate that prevalent forms of psychopathology can be organized into second- order dimensions based on their correlations, including a general factor of psychopathology that explains the common variance among all disorders and specific second-order externalizing and internalizing factors. Despite this organization, and high levels of comorbidity between diagnoses, most existing studies on the neural correlates of psychopathology employ case-control designs that treat diagnoses as independent categories. Thus, for instance, although perturbations in white matter microstructure have been identified across a range of disorders, the majority of such studies have used case-control designs, leaving it unclear whether observed relations reflect disorder specific characteristics, or transdiagnostic patterns. Using a representative community twin sample of 410 young adults, we tested the hypothesis that some relations between white matter microstructure properties in major tracts are related to second- order factors of psychopathology. We examined fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). White matter correlates of all second-order factors were identified after controlling for mul...Continue Reading

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Mentioned in this Paper

Study
Fornix of Vagina
Fanconi Anemia
Entire Fornix of Vagina
Patterns
Structure of Body of Corpus Callosum
Tract
Entire Internal Capsule of Brain
Alzheimer's Disease
RADIN BLOOD GROUP ANTIGEN

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