White matter network topology relates to cognitive flexibility and cumulative neurological risk in adult survivors of pediatric brain tumors

NeuroImage. Clinical
Sabrina NaTricia Z King

Abstract

Adult survivors of pediatric brain tumors exhibit deficits in executive functioning. Given that brain tumors and medical treatments for brain tumors result in disruptions to white matter, a network analysis was used to explore the topological properties of white matter networks. This study used diffusion tensor imaging and deterministic tractography in 38 adult survivors of pediatric brain tumors (mean age in years = 23.11 (SD = 4.96), 54% female, mean years post diagnosis = 14.09 (SD = 6.19)) and 38 healthy peers matched by age, gender, handedness, and socioeconomic status. Nodes were defined using the Automated Anatomical Labeling (AAL) parcellation scheme, and edges were defined as the mean fractional anisotropy of streamlines that connected each node pair. Global efficiency and average clustering coefficient were reduced in survivors compared to healthy peers with preferential impact to hub regions. Global efficiency mediated differences in cognitive flexibility between survivors and healthy peers, as well as the relationship between cumulative neurological risk and cognitive flexibility. These results suggest that adult survivors of pediatric brain tumors, on average one and a half decades post brain tumor diagnosis and tr...Continue Reading

Citations

Jul 10, 2020·Journal of the International Neuropsychological Society : JINS·Rella J KautiainenTricia Z King
Nov 19, 2020·Brain and Behavior·Janine S SpitzhüttlRegula Everts
Jan 31, 2021·Neuropsychology Review·Sarah V ClarkTricia Z King
Apr 23, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shelli R KeslerBrian J Nieman
Oct 5, 2021·Journal of the International Neuropsychological Society : JINS·Matthew C HockingJohn D Herrington

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