White matter pathways as both a target and mediator of health behaviors

Annals of the New York Academy of Sciences
Alexis PorterTimothy Verstynen

Abstract

Health behaviors arise from the dynamics of highly interconnected networks in the brain and variability in these networks drives individual differences in behavior. In this review, we show how many factors that predict the physical health of the body also correlate with variability of the myelinated fascicles, called white matter, that connect brain regions together. The general pattern present in the literature is that as predictors of physical health decline, there is often a coincident reduction in the integrity of major white matter pathways. We also highlight a plausible mechanism, inflammatory pathways, whereby health-related activation of the immune system can impact the myelin sheath, a protective tissue that facilitates long range communication in the brain. The growing body of evidence supports the hypothesis that degrading health in the periphery may disrupt the communication efficiency of the macroscopic neural circuits that mediate complex behaviors, which can in turn contribute to poorer physical health.

References

May 1, 1985·Journal of the Neurological Sciences·A SenaG Rebel
May 1, 1995·The Journal of Clinical Investigation·G S HotamisligilB M Spiegelman
Dec 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C Pierpaoli, P J Basser
Jul 1, 1995·Neuroimmunomodulation·W A BanksR D Broadwell
May 30, 1997·Annals of the New York Academy of Sciences·P J Basser
Jul 9, 1999·The Anatomical Record·S Mori, P B Barker
Sep 25, 1999·The Journal of Endocrinology·C P SewterS O'Rahilly
Jan 12, 2001·Journal of Epidemiology and Community Health·K E Pickett, M Pearl
Mar 22, 2001·Nature·M EkA Ericsson-Dahlstrand
Mar 29, 2001·Journal of Magnetic Resonance Imaging : JMRI·D Le BihanH Chabriat
Oct 30, 2001·The Proceedings of the Nutrition Society·S W Coppack
Dec 26, 2001·Annual Review of Psychology·Robert H Bradley, Robert F Corwyn
Aug 3, 2002·Nature Reviews. Neuroscience·Richard E PassinghamRolf Kötter
Nov 12, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·T S ChurchS N Blair
Apr 12, 2003·Obesity Research·Monica BullóJordi Salas-Salvadó
Nov 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Karine ClémentDominique Langin
Mar 22, 2005·Current Pharmaceutical Design·William A Banks
May 3, 2005·NeuroImage·Sheng-Kwei SongRegina C Armstrong
Jun 21, 2005·Brain, Behavior, and Immunity·Karen Suárez KrabbeHelle Bruunsgaard
Nov 8, 2005·Annals of Epidemiology·Earl S FordLisa F Berkman
Dec 7, 2005·Brain, Behavior, and Immunity·Dawn E AlleyEileen M Crimmins
Jan 31, 2006·Journal of Biosocial Science·Eric B LoucksEmelia J Benjamin
Mar 29, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Annemarie KosterUNKNOWN Health ABC Study
Apr 7, 2007·Annals of the New York Academy of Sciences·Bonita L MarksScott A Huettel
Apr 21, 2007·Journal of Applied Physiology·Mark A Febbraio
Sep 4, 2007·Trends in Neurosciences·Carl W CotmanLori-Ann Christie
Dec 7, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Leslie K JacobsenW Einar Mencl
Jan 12, 2008·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Robert H PaulEvian Gordon
Jun 24, 2008·Brain : a Journal of Neurology·H NeumannR J M Franklin
Jul 9, 2008·Psychosomatic Medicine·Karen L PetersenStephen B Manuck

❮ Previous
Next ❯

Citations

Mar 25, 2019·Neurochemical Research·Christopher S Colwell, Cristina A Ghiani
Jun 21, 2019·Cerebral Cortex·Ursula A TooleyDanielle S Bassett
Jun 23, 2020·Brain Connectivity·Susan L BenearIngrid R Olson
Oct 7, 2020·The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics·Sameer VohraElizabeth Weeks

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Brain and nerve = Shinkei kenkyū no shinpo
Hiroaki Wake, Daisuke Kato
Journal of Dental Research
M W Heft
Frontiers in Bioscience (Landmark Edition)
Clara R FreemanGene-Jack Wang
Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Danielle J Tisserand, J Jolles
The Journal of Osaka University Dental School
S NISHIJIMAS MIYOSHI
© 2022 Meta ULC. All rights reserved