White Matter Structure in Older Adults Moderates the Benefit of Sleep Spindles on Motor Memory Consolidation

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Bryce A ManderMatthew P Walker

Abstract

Sleep spindles promote the consolidation of motor skill memory in young adults. Older adults, however, exhibit impoverished sleep-dependent motor memory consolidation. The underlying pathophysiological mechanism(s) explaining why motor memory consolidation in older adults fails to benefit from sleep remains unclear. Here, we demonstrate that male and female older adults show impoverished overnight motor skill memory consolidation relative to young adults, with the extent of impairment being associated with the degree of reduced frontal fast sleep spindle density. The magnitude of the loss of frontal fast sleep spindles in older adults was predicted by the degree of reduced white matter integrity throughout multiple white matter tracts known to connect subcortical and cortical brain regions. We further demonstrate that the structural integrity of selective white matter fiber tracts, specifically within right posterior corona radiata, right tapetum, and bilateral corpus callosum, statistically moderates whether sleep spindles promoted overnight consolidation of motor skill memory. Therefore, white matter integrity within tracts known to connect cortical sensorimotor control regions dictates the functional influence of sleep spind...Continue Reading

Citations

Sep 22, 2020·Brain Communications·Erlan SanchezNadia Gosselin
Oct 20, 2020·Frontiers in Neuroscience·Bryce A Mander
Mar 7, 2021·Brain Sciences·Maurizio Gorgoni, Luigi De Gennaro
Apr 2, 2021·Pflügers Archiv : European journal of physiology·Diana Campos-Beltrán, Lisa Marshall
May 14, 2021·Sleep Advances : a Journal of the Sleep Research Society·Ariel B NeikrugRuth M Benca
Jun 25, 2021·Brain Communications·Giulio BernardiMichele Bellesi

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