White matter tract myelin maturation and its association with general psychopathology in adolescence and early adulthood

Human Brain Mapping
Lucy D VanesRaymond J Dolan

Abstract

Adolescence is a time period associated with marked brain maturation that coincides with an enhanced risk for onset of psychiatric disorder. White matter tract myelination, a process that continues to unfold throughout adolescence, is reported to be abnormal in several psychiatric disorders. Here, we ask whether psychiatric vulnerability is linked to aberrant developmental myelination trajectories. We assessed a marker of myelin maturation, using magnetisation transfer (MT) imaging, in 10 major white matter tracts. We then investigated its relationship to the expression of a general psychopathology "p-factor" in a longitudinal analysis of 293 healthy participants between the ages of 14 and 24. We observed significant longitudinal MT increase across the full age spectrum in anterior thalamic radiation, hippocampal cingulum, dorsal cingulum and superior longitudinal fasciculus. MT increase in the inferior fronto-occipital fasciculus, inferior longitudinal fasciculus and uncinate fasciculus was pronounced in younger participants but levelled off during the transition into young adulthood. Crucially, longitudinal MT increase in dorsal cingulum and uncinate fasciculus decelerated as a function of mean p-factor scores over the study ...Continue Reading

References

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Related Concepts

Biological Markers
Brain Diseases
Inferior
Cerebral Tracts
Participant
Structure of Superior Fronto-occipital Fasciculus
Superior Sagittal Sinus
Mental Disorders
Psychopathology
Antibody to Myelin Measurement

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